Changes in Tissue Oxygenation and Acidity Induced by Localized Microwave Hyperthermia and Hematoporphyrin Phototherapy, an Update

  • Haim I. Bicher
  • D. F. Bruley
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 159)


Due, in part, to increasing clinical interest, active investigation of the physiological phenomena induced by hyperthermia is in progress (1, 2,7, 13). The studies of Eddy (7) and Reinhold (13) employing “chamber systems” have both shown changes in the micro-vascular network as a function of temperature and exposure time. Cater et al. (3) reported on changes in tumor oxygen tension with hyperthermia but did not record changes in tumor temperature. Bicher (1, 2), in a mouse leg tumor system, reported that tumor blood flow increased up to 41°C and then decreased to 4400. The oxygen tension in the tumor, as measured with a platinum electrode, generally followed the changes in tumor blood flow.


Oxygen Tension Coagulation Necrosis Tumor Blood Flow Histogram Shift Nonnal Tissue 


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Bicher, H. I., Hetzel, F. W., Sandhu, T. S., Frinak, S., Vaupel, P., O’Hara, M. D. and O’Brien, T. Effects of hyperthermia on normal and tumor microenvironment. Radiology, In Press 1980.Google Scholar
  2. 2.
    Bicher, H. I. Increase in brain tissue oxygen availability induced by localized microwave hyperthermia. In Silver, Erecinska, and Bicher, Oxygen transport to tissue; Vol. III, pp. 347–353, Plenum Press, New York, 1978.Google Scholar
  3. 3.
    Cater, D. B. and Silver, I. A. Quantitative measurements of oxygen tension in normal tissues and in the tenors of patients before and after radiotherapy. Acta. Radiologica. 53: 233–256, 1960.PubMedCrossRefGoogle Scholar
  4. 4.
    Cater, D. B., Silver, I. S. and Wilson, G. M. Apparatus and technique for the quantitative measurement of oxygen tension in living tissues. Proc. Roy. Soc., Lond. (Series B) 151: 256–276, 1959–1960.CrossRefGoogle Scholar
  5. 5.
    Diamond, I., McDonagh, A. F., Wilson, C. B., Granelli, S. G., Nielsen, S. and Jaenicke, R. Photodynamic therapy of malignant tumors. Lancet, 2: 1175–1177, 1972.PubMedCrossRefGoogle Scholar
  6. 6.
    Dougherty, T. J., Kaufman, J. E., Goldfarb, A., Weishaupf, K. R., Boyle, D., and Mittleman, A. Photoradiation therapy for the treatment of malignant tumors. Cancer Res. 38: 2628–2633, 1978.PubMedGoogle Scholar
  7. 7.
    Eddy, H. A. Alterations in tumor microvasculature during hyperthermia. Radiology, In Press, 1980.Google Scholar
  8. 8.
    Eden, M., and Kahler, H. The pH of rat tumors measured in vivo. J. Nat’l. Cancer Inst. 16: 541–556, 1955.PubMedGoogle Scholar
  9. 9.
    Gerweck, L. E. Modification of cell lethality at elevated temperatures: The pH effect. Radiat. Res. 70: 224–235 1977.PubMedCrossRefGoogle Scholar
  10. 10.
    Gullino, P. M., Grantham, F. M. and Smith, S. H. Modifications of the acid-base status of the internal milieu of tumors. J. Nat’l. Cancer Inst. 34: 857–860, 1965.PubMedGoogle Scholar
  11. 11.
    Hinke, J. A. Cation-selective microelectrodes for intracellular use. In Eisennan, Glass electrodes for hydrogen and other cations; Marcel Dekker, Inc., New York, 1973.Google Scholar
  12. 12.
    Overgaard, J. Influence of extracellular pH on the viability and morphology of tumor cells exposed to hyperthermia. J. Nat’l. Cancer Inst. 56: 1243–1250, 1976.PubMedGoogle Scholar
  13. 13.
    Reinhold, H. S., Blachiewicz, B., and Berg-Blok, A. V. D. Decrease in tumor microcirculation during hyperthermia. in Streffer, Cancer therapy by hyperthermia and radiation. pp. 231–232, Urban and Schwarzenburg, Baltimore, 1978.Google Scholar
  14. 14.
    T. S., Kowal, H. S., and , R. Development of hyperthermia applicators. Int. J. Radiat. Oncol. Biol. Phys. 4: 515–519, 1978.CrossRefGoogle Scholar
  15. 15.
    Weishaupt, K. R., Garver, C. J. and Dougherty, T. J. Identification of singlet oxygen as the cytotoxic agent in photo-inactivation of a murine tumor. Cancer Res. 36, 23–26, 1976.Google Scholar

Copyright information

© Plenum Press, New York 1983

Authors and Affiliations

  • Haim I. Bicher
    • 1
    • 2
  • D. F. Bruley
    • 1
    • 2
  1. 1.Valley Cancer InstituteWestern Tumor Medical GroupVan NuysUSA
  2. 2.Biomedical Engineering DepartmentLouisiana Tech UniversityRustonUSA

Personalised recommendations