Changes in Tissue Oxygenation and Acidity Induced by Localized Microwave Hyperthermia and Hematoporphyrin Phototherapy, an Update
Due, in part, to increasing clinical interest, active investigation of the physiological phenomena induced by hyperthermia is in progress (1, 2,7, 13). The studies of Eddy (7) and Reinhold (13) employing “chamber systems” have both shown changes in the micro-vascular network as a function of temperature and exposure time. Cater et al. (3) reported on changes in tumor oxygen tension with hyperthermia but did not record changes in tumor temperature. Bicher (1, 2), in a mouse leg tumor system, reported that tumor blood flow increased up to 41°C and then decreased to 4400. The oxygen tension in the tumor, as measured with a platinum electrode, generally followed the changes in tumor blood flow.
KeywordsOxygen Tension Coagulation Necrosis Tumor Blood Flow Histogram Shift Nonnal Tissue
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