The Use of a Peroxidase Electrode to Measure the Effects of Nitro Compounds on Intact Cells

  • Marie E. Varnes
  • Stephen W. Tuttle
  • John E. Biaglow
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 159)


Metabolic reduction of nitro compounds in mammalian cells results in formation of intermediates, principally nitro radical anions, which can react with cellular oxygen (4,5,9).


Uric Acid Xanthine Oxidase H202 Production Nitro Compound Electrode Response 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Benade, L., Howard, T., and Burk, D., Oncology 23, 33–43, 1969.PubMedCrossRefGoogle Scholar
  2. 2.
    Biaglow, J. E., Jacobson, B., Greenstock, C. L., and Raleigh, J., Mol. Pharmac. 13, 269–282, 1977.Google Scholar
  3. 3.
    Biaglow, J. E., Jacobson, B. E., and Nygaard, O. F., Can. Res. 37, 3306–3313, 1977.Google Scholar
  4. 4.
    Biaglow, J. E., Pharmac. Ther. 10, 283–299, 1980.CrossRefGoogle Scholar
  5. 5.
    Biaglow, J. E., Rad. Res. 86, 212–242, 1981.CrossRefGoogle Scholar
  6. 6.
    Biaglow, J. E., Varnes, M. E., Sridhar, R., and Koch, C. J., in Free Radicals and Cancer, (R. Floyd, ed.), Plarcel Dekker, New York, pp. 441–502, 1982.Google Scholar
  7. 7.
    Clark, L. C., Methods in Enzymol. 56, 448–479, 1979.CrossRefGoogle Scholar
  8. 8.
    Miller, R. C. and Hall, E. J., in Radiation Sensitizers: Their Use in the Clinical Management of Cancer, (L. Brady, ed.) Masson Publ. Co., New York, pp. 146–151, 1980.Google Scholar
  9. 9.
    Perez-Reyes, E., Kalyanaraman, B., and Mason, R., Mol. Pharmac. 17, 239–244, 1979.Google Scholar
  10. 10.
    Schroy, C. B. and Biaglow, J. E., Biochem. Pharmac., 30, 3201 1981.CrossRefGoogle Scholar
  11. 11.
    Varnes, M. E., Biaglow, J. E., and Olive, P. L., in Oxygen and Oxy-radicals in Chemistry and Biology, (L. Powers and M. Rogers, eds.) Academic Press, New York, pp. 766–768, 1981.Google Scholar

Copyright information

© Plenum Press, New York 1983

Authors and Affiliations

  • Marie E. Varnes
    • 1
  • Stephen W. Tuttle
    • 1
  • John E. Biaglow
    • 1
  1. 1.Department of Radiology, Division of Radiation BiologyCase Western Reserve UniversityClevelandUSA

Personalised recommendations