Advertisement

DPG — A Link between Blood Acid-Base Status and Respiratory Function

  • Jerry H. Meldon
  • Omar K. Abboud
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 159)

Abstract

The intimate connection between the acid-base status and respiratory function of blood is a fundamental concept of physiology. Recognition of this fact effectively dates back to the report by Bohr et al. (1904) of the effect of CO2 on the oxyhemglobin dissociation curve (ODC), since it later became clear that CO2-mediated pH changes are primarily responsible for the “Bohr effect”.

Keywords

Respiratory Function Oxygen Transport Intimate Connection Bohr Effect Allosteric Binding 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Arturson, G., Garby, L., Robert, M. and Zaar, B. Scand. J. Clin. Lab. Invest. 34, 9, 1974.PubMedCrossRefGoogle Scholar
  2. Astrup, P., Rørth, M. and Thorshauge, C. Scand. J. Clin. Lab. Invest. 26, 47, 1970.PubMedCrossRefGoogle Scholar
  3. Benesch, R. and Benesch, R. E. Biochem. Biophys. Res. Commun. 26, 162, 1967.PubMedCrossRefGoogle Scholar
  4. Bohr, C., Hasselbalch, K. A. and Krogh, A. Scand. Arch. Physiol. 16, 402, 1904.CrossRefGoogle Scholar
  5. Chanutin, A. and Curnish, P. Arch. Biochem. Biophys. 121, 96, 1967.PubMedCrossRefGoogle Scholar
  6. Duhm, J. Pflügers Arch. 326, 341, 1971.PubMedCrossRefGoogle Scholar
  7. Duhm, J. and Gerlach, E. Pflügers Arch. 326, 254, 1971.PubMedCrossRefGoogle Scholar
  8. Garby, L. and Meldon, J. H. The Respiratory Functions of Blood ( New York: Plenum Med. Publ. Corp. ), 1977.CrossRefGoogle Scholar
  9. Heineken, F. G. and Lobdell, D. D. Respir. Physiol. 26, 277, 1976.CrossRefGoogle Scholar
  10. Lichturan, M. A., Murphy, M. S., Whitbeck, A. A. and Kearney, E. A. Brit. J. Haemat. 27, 439, 1974.CrossRefGoogle Scholar
  11. Lloyd, B. B. and Michel, C. C. Respir. Physiol. 1, 107, 1966.PubMedCrossRefGoogle Scholar
  12. Meldon, J. H. and Garby, L. Acta. Med. Scand. Suppl. 578, 19, 1975.PubMedGoogle Scholar
  13. Meldon, J. H. and Garby, L. Adv. Exp. Med. Biol. 75, 241, 1976.PubMedGoogle Scholar
  14. Olszowka, A. J., Rahn, H. and Farhi, L. E. Blood Gases: Hemoglobin, Base Excess and Maldistribution ( Philadelphia: Lea and Febiger, 1973.Google Scholar
  15. Rapoport, S. M. and Guest, G., J. Biol. Chem. 131, 675, 1939.Google Scholar
  16. Reeves, R. B, J. Appl. Physiol. 40, 762, 1976.PubMedGoogle Scholar
  17. Rodeau, J. L. and Malan, A. Respir. Physiol. 37, 5, 1979.PubMedCrossRefGoogle Scholar
  18. Rørth, M. Scand. J. Clin. Lab. Invest. 26, 43, 1970.PubMedCrossRefGoogle Scholar
  19. Samaja, M. and Winslow, R. M. Brit. J. Haemat. 41, 373, 1979.PubMedCrossRefGoogle Scholar
  20. Siggaard-Anderson, O. The Acid-Base Status of the Blood ( Copenhagen: Munskgaard ), 1974.Google Scholar
  21. Spender, J. L., Firourtale, E. and Mellins, R. B. Ann. Bicmed. Eng. 7, 59, 1979.CrossRefGoogle Scholar
  22. Takasugi, S., Morton, P., Lindberg, D. A. B. and DeLand, E. C. Cumputers and Bicaned. Res. 13, 317, 1980.CrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1983

Authors and Affiliations

  • Jerry H. Meldon
    • 1
  • Omar K. Abboud
    • 1
  1. 1.Chemical Engineering DepartmentTufts UniversityMedfordUSA

Personalised recommendations