Oxygen Consumption Profiles Inside Cellular Spheroids Calculated from Po2 Profiles

  • U. Grossmann
  • J. Carlsson
  • H. Acker
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 159)

Abstract

In order to study the influence of oxygen supply on the development of necrotic zones in tumors Carlsson et al (1979) measured Po2 profiles inside cellular spheroids. Our aim is to calculate oxygen consumption profiles from these measured pO2 values. It is especially interesting to know if the oxygen consumption decreases significantly with depth in the spheroids. If so, consumption variations probably must be considered when the size of oxygen depleted zones are calculated for tumor tissue. We consider the stationary diffusion equation under the assumption of spherical symmetry, constant oxygen conductivity, and a linear oxygen consumption profile (including homogeneous oxygen consumption).

Keywords

Osteosarcoma 

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Copyright information

© Plenum Press, New York 1983

Authors and Affiliations

  • U. Grossmann
    • 1
    • 2
  • J. Carlsson
    • 1
    • 2
  • H. Acker
    • 1
    • 2
  1. 1.Max-Planck-Institut für SystemphysiologieDortmund 1Germany
  2. 2.Dept. Rad. Biol.National Defense Res. Inst.UmeaSweden

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