Relationship Between Size and Oxygenation Status of Malignant Tumors

  • R. Manz
  • J. Otte
  • G. Thews
  • P. Vaupel
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 159)

Abstract

During advanced phases of malignant growth, there are typical changes in the microvasculature pattern within the tissue of many solid tumors. Partly due to these peculiarities of tumor vascularization, a series of characteristic variations of tumor microcirculation occurs (for a review see 1). These alterations lead not only to marked restrictions and inhomogeneities of both convective and diffusive transport but also to an impairment of the efficiency of antitumor therapies.

Keywords

Dioxide Adenocarcinoma Heparin Eter Bark 

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References

  1. 1.
    Vaupel, P., Frinak, S., Bicher, H. I. Heterogeneous oxygen partial pressure and pH distribution in C3H mouse mammary adenocarcinama. Cancer Res. 41, 2008–2013, 1981.PubMedGoogle Scholar
  2. 2.
    Vaupel, P. Oxygen supply to malignant tumors. In: H. I. Peterson (Ed.), Tumor Blood Circulation: Angiogenesis, Vascular Morphology and Blood Flow of Experimental and Human tumors, pp. 143–168. Boca Raton, Fla. CRC Press, 1979.Google Scholar
  3. 3.
    Vaupel, P. Hypoxia in neoplastic tissue. Microvasc. Res. 13, 399–408, 1977.CrossRefGoogle Scholar
  4. 4.
    Vaupel, P., Wendling, P., Thews, G., Kritische Sauerstofund Glucoseversorgung maligner Tumoren. Dtsch. med. Wochenschr. 101, 1810–1816, 1976.CrossRefGoogle Scholar
  5. 5.
    Constable, T. B., Evans, N. T. S. The distribution of oxygen consumption rates in sane tissues before and after X–irradiation. Advan. exp. Med. Biol. 75, 611–617, 1976.Google Scholar
  6. 6.
    Bork, R., Vail, P., Gunther, H., Thews, G., Atemgas pH-LNomogramme fUr das Rattenblut bei 37°C. Anaesthesist 24, 84–90, 1975.PubMedGoogle Scholar
  7. 7.
    Grunewald, W. A., Lübbers, D. W., Kryophotometry as a method for analyzing the intracapillary HbO2 saturation of organs under different 02 supply conditions. Alvan. exp. Med. Biol. 75, 55–64, 1976.Google Scholar
  8. 8.
    Vaupel, P., Manz, R., Miller-Kleiser, W., Grunewald, W. A., Intracapillary HbO2 saturation in malignant tumors during normoxia and hyperoxia. Microvasc. Res. 17, 18 1191, 1979.Google Scholar
  9. 9.
    Acker, H., Carlsson, J. Oxygen gradients in cellular spheroids cultured at different oxygen concentrations. Pflügers Arch. (Europ. J. Physiol.) 389, R 54, 1981.Google Scholar
  10. 10.
    Carlsson, J. Tumor models in vitro - A study of proliferation and growth in cellular spheroids. Doctoral thesis, Uppsala University, 1978.Google Scholar
  11. 11.
    Sutherland, R., Carlsson, J., Durand, R., Yuhas, J. Spheroids in cancer research (Meeting report). Cancer Res. 41, 2980–2984, 1981.Google Scholar
  12. 12.
    Hilmas, D. E., Gillette, E. L. Microvasculature of C3H/Bi mouse mammary tumors after X-irradiation. Radiat. Res. 61, 128–143, 1975.PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1983

Authors and Affiliations

  • R. Manz
    • 1
    • 2
  • J. Otte
    • 1
    • 2
  • G. Thews
    • 1
    • 2
  • P. Vaupel
    • 1
    • 2
  1. 1.Department of PhysiologyUniversity of RegensburgRegensburgWest Germany
  2. 2.Department of PhysiologyUniversity of MainzMainzWest Germany

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