Oxygen Multistep Immunostimulation — A New Concept for Improving the Immune State in Cancer Patients

  • Manfred von Ardenne
  • Winifried Krüger
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 159)


Oxygen Multistep Immunostimulation (OMI) represents a further development or a special branch of the Oxygen Multistep Therapy (OMT) which was inaugurated about 5 years ago. Although a book on the latter was published already in its 3rd edition (1), this more or less empirically found method seems to be still widely unknown, so that it will be useful to resume briefly its main features. The starting point of our investigations was an observation made by Loew and Thews as early as in 1962 (2) on the age-dependency of the arterial oxygen partial pressure (paO2) measured in a representative part of the working population in West Germany. As can be taken from the original graph (Fig. 1), the paO2 decreases with progressing age and amounts only to about 70% in old age as compared to values detectable in juveniles. Since the degree of saturation of hemoglobin depends on the arterial oxygen partial pressure the oxygen supply of all tissues must be proportionally suboptimal at lowered paO2. The oxygen supply becomes, therefore, the limiting factor as to energy production in all tissues and, hence, the primary cause of multiple discomforts, several ailments and diseases in old age. The inner vessel walls seen to be one of the primary points of attack. Oxygen-deficient endothelial cells begin to swell resulting in blood flow reduction so that a vicious circle emerges (Fig. 2). In brief, there are many reasons for permanently improving the oxygen supply in aged humans. Until very recently, however, the age-dependent decrease of the arterial pO2 was considered to be irreversible and refractory.


Oxygen Supply Body Weight Change Orotic Acid Arterial Oxygen Partial Pressure Thymus Extract 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    von Ardenne, M., “Sauerstoff-Mehrschritt-Therapie”, 3rd ed., Stuttgart and New York, Thieme, 1983.Google Scholar
  2. 2.
    Loew,’P. G., Thews, G., Die Altersabhängigkeit des arteriellen Sauerstoffdruckes bei der berufstätigen Bevölkerung. Klin Wschr 40: 1093, 1962.PubMedCrossRefGoogle Scholar
  3. 3.
    Lippmann, H. G., Energiereiche Phosphate, Glukose, Laktat und Pyruvat im Hirn der Ratte unter Anderung des p02 der Inspirationsluft. Acta biol med germ 27: 805, 1971.PubMedGoogle Scholar
  4. 4.
    von Ardenne, M., Measurement and Removal of Certain Stress Effects. Stress 2: 25, 1981.Google Scholar
  5. 5.
    Fischer, H., Staudinger, H. J., Chemilumineszenz, ein Indikator für Zellaktivierung? Klin Wschr 59: 199, 1981.PubMedCrossRefGoogle Scholar
  6. 6.
    Kato, T., Wokalek, H., Schopf, E., Eggert, H., Ernst, M., Rietschel E. T. H., Fischer, H.: Measurements of Chemiluminescence in Freshly Drawn Human Blood. I. Role of Granulocytes, Platelets, and Plasma Factors in Zymosan-induced Chemiluminescence. Klin Wschr 59: 203, 1981.PubMedCrossRefGoogle Scholar
  7. 7.
    von Ardenne, M. Krebs-Rezidiv-und Metastasen-Prophylaxe durch 02-Mehrschritt-ImMunstimulation. Arztezeitschr f Naturheilverf 22: 318, 1981.Google Scholar
  8. 8.
    Wehrli, F.: Über die hämatogene Oxydationstherapie. Hippokrates 29: 551, 1958.PubMedGoogle Scholar
  9. 9.
    von Ardenne, M., Wiemuth, H. H., Wiesner, S.: I’essungen über permanente bzw. zeitweilige Steigerung der arteriovenösen p02-Differenz durch den 02-Mehrschritt-Regenerationsprozeß bzw. Reinfusion von UV-bestrahltem Eigenblut. Dtsch Gesundh Wes 35: 1620, 1980.Google Scholar
  10. 10.
    Friedman, H. (Ed.) Thymus Factors in Immunity (Proceedings). Ann. NY Acad Si 249, 1975.Google Scholar
  11. 11.
    Micksche, M., Cerni, C., Kokron, O., Titscher, R., Wrba, H.: Ininunstimulierung bei Lungenkrebspatienten durch VitaminA-Therapie. Onkologie 1: 57, 1978.PubMedCrossRefGoogle Scholar
  12. 12.
    von Ardenne, M., Reitnauer, P. G.: Nachweis krebshemmender Eigenschaften einer stark imrninstimulierenden Verbindung kleiner Nblekülmasse. Arzneimittelforsch 25: 1369, 1975.PubMedGoogle Scholar
  13. 13.
    von Ardenne, M., Reitnauer, P. G., Krüger, W.: 2-Cyanoethyl Urea and Its Derivatives as Potential Irrnunostimulants in Experimental Cancer Therapy. Arch Geschwulstforsch 51: 485, 1981.Google Scholar

Copyright information

© Plenum Press, New York 1983

Authors and Affiliations

  • Manfred von Ardenne
    • 1
  • Winifried Krüger
    • 1
  1. 1.Research Institute Manfred von ArdenneDresdenGDR

Personalised recommendations