Inhibition of Cultured Human Tumor Cell Oxygen Utilization by Chlorpromazine
Chlorpromazine hydrochloride (CPZ) a widely used tranquilizer was earlier shown to preferentially sensitize hypoxic bacterial cells to 60Co gamma rays (Shenoy, George, Singh & Ayengar, 1975). CPZ was also observed to be toxic towards hypoxic cells (Shenoy & Singh, 1978) and this hypoxic cytotoxicity was found to be dependent on temperature. When tested in murine tumors, the drug sensitized Sarcoma 180A (Shenoy & Singh, 1980) as well as fibrosarcoma (George Srinivasan & Singh, 1980) to x-rays. A marked chemotherapeutic effect of CPZ was evident in Sarcoma 180A (Shenoy & Singh, 1980) and this effect was more pronounced in clamped tumors (George et al., 1980), indicating the effectiveness of the drug when cells were under acute hypoxia.
KeywordsHypoxic Cell Ehrlich Ascites Tumor Chlorpromazine Hydrochloride NPSH Level Cellular OXygen Consumption
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