Inhibition of Cultured Human Tumor Cell Oxygen Utilization by Chlorpromazine

  • M. A. Shenoy
  • J. E. Biaglow
  • M. E. Varnes
  • F. W. Hetzel
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 159)


Chlorpromazine hydrochloride (CPZ) a widely used tranquilizer was earlier shown to preferentially sensitize hypoxic bacterial cells to 60Co gamma rays (Shenoy, George, Singh & Ayengar, 1975). CPZ was also observed to be toxic towards hypoxic cells (Shenoy & Singh, 1978) and this hypoxic cytotoxicity was found to be dependent on temperature. When tested in murine tumors, the drug sensitized Sarcoma 180A (Shenoy & Singh, 1980) as well as fibrosarcoma (George Srinivasan & Singh, 1980) to x-rays. A marked chemotherapeutic effect of CPZ was evident in Sarcoma 180A (Shenoy & Singh, 1980) and this effect was more pronounced in clamped tumors (George et al., 1980), indicating the effectiveness of the drug when cells were under acute hypoxia.


Hypoxic Cell Ehrlich Ascites Tumor Chlorpromazine Hydrochloride NPSH Level Cellular OXygen Consumption 
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Copyright information

© Plenum Press, New York 1983

Authors and Affiliations

  • M. A. Shenoy
    • 1
    • 2
  • J. E. Biaglow
    • 1
    • 2
  • M. E. Varnes
    • 1
    • 2
  • F. W. Hetzel
    • 1
    • 2
  1. 1.Division of Radiation Biology — Radiobiological Sciences & Hyperthermia DivisionHenry Ford HospitalDetroitUSA
  2. 2.Case Western Reserve UniversityClevelandUSA

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