Hypoxia and the Radiation Response of Tumors

  • R. P. Hill
  • M. G. Pallavicini
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 159)


The effect of hypoxia on the in vivo radiation response of, tumors is demonstrated both for the measurement of cell survival and growth delay following treatment. Results using these endpoints for the KHT Sarcoma are then presented to demonstrate the effect of various parameters which are expected to control tumor oxygenation: blood flow, blood pO2, blood oxygen carrying capacity and tissue consumption of oxygen. Intrinsic blood flow does not correlate with the level of hypoxia in the tumor, but acute reductions in blood flow do result in decreases in tumor oxygenation. Changing the blood PaO2 or the oxygen carrying capacity change the level of hypoxia as predicted, but only certain aspects have been studied. The intricate feedback mechanism which controls normal tissue oxygenation and compensates for any deficiencies cannot be assumed to work effectively in tumors.


Blood Flow Hyperbaric Oxygen Growth Delay Hypoxic Cell Radiation Response 


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Copyright information

© Plenum Press, New York 1983

Authors and Affiliations

  • R. P. Hill
    • 1
  • M. G. Pallavicini
    • 1
  1. 1.Ontario Cancer InstituteIncorporating The Princess Margaret HospitalTorontoCanada

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