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Metabolic Effects of Lowering Oxygen Tension In Vivo

  • David F. Wilson
  • Maria Erecinska
  • Ian A. Silver
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 159)

Abstract

The delivery of oxygen to tissue is a highly regulated process which requires the existence of a tissue oxygen sensing mechanism. This sensor must be able to measure accurately the oxygen tension in each localized region of tissue and then transmit this information to the point of the control system which regulates the resistance of the appropriate blood vessels. Approximately 95% of the oxygen consumed by most tissues is utilized for mitochondrial oxidative phosphorylation through reaction with cytochrome c oxidase and it would be reasonable to assume that O2 delivery is regulated primarily to maintain this critical metabolic function. The question arises, is mitochondrial oxidative phosphorylation itself the oxygen sensor?

Keywords

Respiratory Rate Oxygen Tension Turnover Number Mitochondrial Oxidative Phosphorylation Lowering Oxygen Tension 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1983

Authors and Affiliations

  • David F. Wilson
    • 1
    • 2
  • Maria Erecinska
    • 1
    • 2
  • Ian A. Silver
    • 1
    • 2
  1. 1.Department of Biochemistry & BiophysicsUniversity of PennsylvaniaPhiladelphiaUSA
  2. 2.Department of PathologyUniversity of BristolBristolEngland

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