Metabolic Effects of Lowering Oxygen Tension In Vivo
The delivery of oxygen to tissue is a highly regulated process which requires the existence of a tissue oxygen sensing mechanism. This sensor must be able to measure accurately the oxygen tension in each localized region of tissue and then transmit this information to the point of the control system which regulates the resistance of the appropriate blood vessels. Approximately 95% of the oxygen consumed by most tissues is utilized for mitochondrial oxidative phosphorylation through reaction with cytochrome c oxidase and it would be reasonable to assume that O2 delivery is regulated primarily to maintain this critical metabolic function. The question arises, is mitochondrial oxidative phosphorylation itself the oxygen sensor?
KeywordsRespiratory Rate Oxygen Tension Turnover Number Mitochondrial Oxidative Phosphorylation Lowering Oxygen Tension
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