Abstract
Oxidative phosphorylation is a requisite for production of cellular energy, since brain function is strongly dependent on ATP availability. It is well-known that cerebrovascular disturbances are accompanied by metabolic and morphological alterations in brain tissue, especially at the mitochondria) level. However, the degree of reversibility of changes such as mitochondria) swelling is not defined. Until recently, these pathological modifications could not be studied in vivo due to lacking methodology. Although data concerning mitochondria) changes following ischemia are available, they have essesntially been obtained in vitro or ex vivo. Accordingly, they have to be interpreted with caution, as considerable evidence exists for a discrepancy in the behaviour of the respiratory chain in vivo and in vitro (Sanjen and Rosenthal, 1979).
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Wiernsperger, N., Gygax, P. (1983). Incomplete Cerebral Ischemia in the Rat: Vascular and Metabolic Changes as Measured by Infrared Transillumination In Vivo. In: Bicher, H.I., Bruley, D.F. (eds) Oxygen Transport to Tissue—IV. Advances in Experimental Medicine and Biology, vol 159. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-7790-0_2
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