Incomplete Cerebral Ischemia in the Rat: Vascular and Metabolic Changes as Measured by Infrared Transillumination In Vivo

  • N. Wiernsperger
  • P. Gygax
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 159)


Oxidative phosphorylation is a requisite for production of cellular energy, since brain function is strongly dependent on ATP availability. It is well-known that cerebrovascular disturbances are accompanied by metabolic and morphological alterations in brain tissue, especially at the mitochondria) level. However, the degree of reversibility of changes such as mitochondria) swelling is not defined. Until recently, these pathological modifications could not be studied in vivo due to lacking methodology. Although data concerning mitochondria) changes following ischemia are available, they have essesntially been obtained in vitro or ex vivo. Accordingly, they have to be interpreted with caution, as considerable evidence exists for a discrepancy in the behaviour of the respiratory chain in vivo and in vitro (Sanjen and Rosenthal, 1979).


Blood Volume Vertebral Artery Cerebral Blood Volume Vessel Occlusion Carotid Occlusion 
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Copyright information

© Plenum Press, New York 1983

Authors and Affiliations

  • N. Wiernsperger
    • 1
  • P. Gygax
    • 1
  1. 1.Preclinical ResearchSandoz Ltd.BasleSwitzerland

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