Evidence for the Blood Oxygen Boundary Layer pO2 Gradient (ΔpO2) as a Significant Determinant of Intimal (PW) and Lowest Medial pO2 (pδn) in the Vivo Dog Femoral Artery

  • Donald W. Crawford
  • Mark A. Cole
  • Lloyd H. Back
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 159)


For a considerable number of years, accumulating evidence from the biochemical laboratory has suggested that intimal thickening, perhaps as a part of the atherosclerotic process, is associated with hypoxia of portions of the arterial wall (1–3). This hypoxia has in turn been associated with the further development or acceleration of atherosclerosis, based on observations such as the increased incorporation of cholesterol into cultured myocytes at low levels of oxygen tension (4).


Arterial Wall Oxygen Partial Pressure Oxygen Transport Oxygen Flux External Elastic Lamina 


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Copyright information

© Plenum Press, New York 1983

Authors and Affiliations

  • Donald W. Crawford
    • 1
    • 2
  • Mark A. Cole
    • 1
    • 2
  • Lloyd H. Back
    • 1
    • 2
  1. 1.Department of MedicineCardiology Division, University of Southern California School of MedicineLos AngelesUSA
  2. 2.Jet Propulsion LaboratoryPasadenaUSA

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