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Local PO2 and Unit Activity Measured with an Oxygen Microelectrode from the Gerbil Cerebral Cortex During Seizure and Eeg Suppression

  • Richard M. Martin
  • James H. HalseyJr.
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 159)

Abstract

In a series of past experiments where we measured the rate of oxygen disappearance with ischemic onset during seizure induced by penthylentetrazole (PTZ), we noted occasions where during major discharges in the EEG the tissue PO2 was driven to zero and remained there for more than thirty seconds. This was intriguing, and we wondered about those neurons at the locus of PO2 measurement, and how they would respond to the hypoxia together with the metabolic demand of the seizure state. Recently, we have acquired the capability to simultaneously measure PO2 and unit activity from the same PO2 microelectrode, and thus the opportunity was presented to perform experiments to address this question.

Keywords

Unit Activity Seizure State Major Discharge Dental Canent Male Gerbil 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1983

Authors and Affiliations

  • Richard M. Martin
    • 1
  • James H. HalseyJr.
    • 1
  1. 1.Department of Neurology, University of Alabama Medical CenterUniversity of Alabama in BirminghamBirminghamUSA

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