Cerebrovascular Responses to Oxygen During Barbiturate Anesthesia

  • Tadashi Shinozuka
  • Edwin M. Nemoto
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 159)


In a previous study we reported that increases in local cerebral blood flow (1CBF) during progressive reduction of PaO2 from 300 to 40 torr was casually related to an increase in cortical hydrogen ion concentration (H+)t (Shinozuka and Nemota, this Symposium). Brain tissue PO2 (PtO2) was also linearly related to (H+)t suggesting that a fall in PtO2 caused an increase in (H+)t which affected 1CBF.


Parietal Cortex Pyridine Nucleotide Pentobarbital Anesthesia Local Cerebral Blood Flow Hydrogen Clearance 
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Copyright information

© Plenum Press, New York 1983

Authors and Affiliations

  • Tadashi Shinozuka
    • 1
  • Edwin M. Nemoto
    • 1
  1. 1.The Anesthesia and CCM Research Laboratoires, Department of Anesthesiology and Critical Care MedicineUniversity of Pittsburgh School of MedicinePittsburghUSA

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