Dynamics of Cerebrovascular Responses to Oxygen

  • Tadashi Shinozuka
  • Edwin M. Nemoto
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 159)


The generation of vasoactive metabolites (Siesjo et al, 1971; Kogure et al, 1977) and ions (Dora et al, 1979) or their release into the extracellular space provides an ample explanation for the accompanying cerebrovascular dilation when arterial PO2 (PaO2) is reduced below 40 torr (Borgstrom et al, 1975). However, changes in cerebral blood flow (CBF) with alterations in PaO2 between 50 torr and higher which may reduce local cortical CBF (1CBF) by 80% (Leniger-Follert et al, 1976) are unexplained by changes in brain lactate and other metabolites (Siesjo et al, 1971: Kogure et al, 1977; Dora et al, 1979). Changes in 1CBF, brain tissue PO2 (PtO2), and pH have not been systematically studied over PaO2s ranging tram hyperoxia to moderate hypoxia. Our aim in this study was to determine whether changes in brain hydrogen ion concentration ((H+)) could account for alterations in cerebrovascular tone when PaO2 is reduced from hyperoxic to moderately hypoxic levels. Local tissue steady-state measurements over a wide range of PaO2 may provide a higher resolution than whole brain or regional measurements and enable the detection of more subtle changes than abrupt, acute and severe hypoxic insults (Dora et al, 1979).


Cerebral Blood Flow Hypoxic Hypoxia Brain Lactate Cerebral Blood Flow Response Cerebrovascular Response 
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Copyright information

© Plenum Press, New York 1983

Authors and Affiliations

  • Tadashi Shinozuka
    • 1
  • Edwin M. Nemoto
    • 1
  1. 1.The Anesthesia and CCM Research Laboratories, Department of Anesthesiology and Critical Care MedicineUniversity of Pittsburgh School of MedicinePittsburgUSA

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