The Transport of Oxygen, Glucose, Carbon Dioxide and Lactic Acid in the Human Brain: Mathematical Models

  • R. S. Artigue
  • D. F. Bruley
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 159)


Mathematical models of the transport of oxygen, glucose, carbon dioxide and lactic acid in the human brain have been developed and solved for both steady-state and dynamic cases which include normal conditions, arterial and venous hypoxia, reduced flow and hematocrit, hypocapnia, reduced glucose and transient arterial upsets. Results indicate that local concentration deficits of oxygen and/or glucose and excesses of lactic acid can exist within the system described by the models and therefore possibly could exist in the tissues of the human brain under similar conditions.


Lactic Acid Lactic Acid Concentration Bohr Effect Finite Difference Technique Oxygen Dissociation Curve 
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Copyright information

© Plenum Press, New York 1983

Authors and Affiliations

  • R. S. Artigue
    • 1
  • D. F. Bruley
    • 2
  1. 1.Rose-Hulman Institute of TechnologyTerre HauteUSA
  2. 2.Louisiana Tech UniversityRustonUSA

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