Platelet Survival Determination in Atherosclerosis

  • Edward Genton
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 104)


It has been convincingly established that the blood platelet plays a key and often primary role in thrombosis, especially in the arterial circulation. Mounting evidence indicates that the thrombotic process plays a major role in atherosclerosis. Whether the process is involved with the initiation of atherosclerotic lesions, as increasing evidence suggests, is not firmly established; but there seems no doubt that thromboembolism contributes greatly to the progression of atherosclerosis and to the clinical complications of the process, such as stroke or myocardial infarction. The blood platelet may contribute to degenerative vascular disease in a number of ways, including that the substances they release upon stimulation actually cause vessel injury or produce a response of the vessel to injury; that they constitute a major component of the thrombi which form on an area of arterial damage or atherosclerotic plaque which may lead to vessel occlusion or serve as a source of emboli that contributes to organ ischemia (1).


Atherosclerotic Lesion Thrombotic Thrombocytopenic Purpura Blood Platelet Platelet Function Test Arterial Thromboembolism 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Mustard, J.F. (1976) Transactions of American Clinical and Climatological Association 87, 104–127.Google Scholar
  2. 2.
    Aster, R.H., and Jandl, J.H. (1964) J. Clin. Invest. 43, 843–855.PubMedCrossRefGoogle Scholar
  3. 3.
    Harker, L.A., Ross, R., Slichter, S.J., and Scott, C.R. (1976) J. Clin. Invest. 58, 731–741.PubMedCrossRefGoogle Scholar
  4. 4.
    Abrahamsen, A.F. (1968) Scand. J. Hemat. 5, 53–63.CrossRefGoogle Scholar
  5. 5.
    Cazenave, J.P., Packham, M.A., Guccione, M.A., and Mustard J.F. (1974) J. Lab. Clin. Med. 86, 551–563.Google Scholar
  6. 6.
    Reimers, H.J., Kinlough-Rathbone, R.L., Cazenave, J.P., Senyi, A.F., Hirsh, J., Packham, M.A., and Mustard, J.F. (1976) Thrombosis and Haemost. 35, 151–166.Google Scholar
  7. 7.
    Groves, H.M., Kinlough-Rathbone, R.L., Richardson, M., and Mustard, J.F. Blood. In press.Google Scholar
  8. 8.
    Ross, R., and Harker, L. (1976) Science 193, 1094–1100.PubMedCrossRefGoogle Scholar
  9. 9.
    Genton, E. (1976) Proceedings of Int’l Symposium on Platelets and Thrombosis, Milan, Italy.Google Scholar
  10. 10.
    O’Neill, B., and Firkin, B. (1964) J. Lab. Clin. Med. 64, 188–201.PubMedGoogle Scholar
  11. 11.
    Abrahamsen, A.F. (1968) Scand. J. Hemat. 5, Suppl. 3, 1–53.Google Scholar
  12. 12.
    Abrahamsen, A.F., Eika, C., Godal, H.C., and Lorentsen, E. (1974) Scand. J. Hemat. 13, 241–245.CrossRefGoogle Scholar
  13. 13.
    Harker, L.A., and Slichter, S.J. (1974) Thromb. Diath. Haemorrh. 31, 188–203.PubMedGoogle Scholar
  14. 14.
    Steele, P.P., Battock, D., and Genton, E. (1975) Circulation 52, 473–476.PubMedCrossRefGoogle Scholar
  15. 15.
    Ritchie, J.L., and Harker, L.A. (1974) Circulation 50, Suppl. 3, 285.Google Scholar
  16. 16.
    Murphy, E.A., and Mustard, J.F. (1962) Circulation 25, 114–125.PubMedCrossRefGoogle Scholar
  17. 17.
    Jonker, J.J., Veen, M.R., Schopman, W., and den Ottolander, G.J.G. (1974) Thromb. Res. 4, 65–67.PubMedCrossRefGoogle Scholar
  18. 18.
    Ritchie, J.L., and Harker, L.A. (1977) Am. J. Cardiol. 39, 595–598.PubMedCrossRefGoogle Scholar
  19. 19.
    Salky, N., and Dugdale, M. (1973) Am. J. Cardiol. 32, 612–617.PubMedCrossRefGoogle Scholar
  20. 20.
    Weily, H.S., Steele, P.P., Davies, H., Pappas, G., and Genton, E. (1974) N. Engl. J. Med. 290, 534–537.PubMedCrossRefGoogle Scholar
  21. 21.
    Steele, P.P., Weily, H.S., Davies, H., and Genton, E. (1974) N. Engl. J. Med. 290, 537–539.PubMedCrossRefGoogle Scholar
  22. 22.
    Steele, P.P., Battock, D., Pappas, G., and Genton, E. (1976) Circulation 53, 685–687.PubMedCrossRefGoogle Scholar
  23. 23.
    Abrahamsen, A.F., Eika, C., Godal, H.C., and Lorentsen, E. (1974) Scand. J. Hemat. 13, 241–245.CrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1978

Authors and Affiliations

  • Edward Genton
    • 1
  1. 1.Faculty of Health SciencesMcMaster UniversityHamiltonCanada

Personalised recommendations