Summary of Workshop 2b: Lipid-Membrane Interactions of Platelets and Coagulation with the Arterial Wall
Both platelets and the arterial wall contain enzymes capable of converting arachidonic acid into the prostaglandin endoperoxides, PGG2 and PGH2. These endoperoxides are subsequently metabolized in platelets into thromboxane A2 which causes platelet aggregation and is a potent vasoconstrictor. By contrast, the endoperoxides are converted in the arterial wall into prostacyclin, a potent inhibitor of platelet aggregation and vasodilator. In the presence of isomerases, the endoperoxides are converted into PGE2 or PGD2.
KeywordsCholesteryl Ester Hydrolase Prostaglandin Endoperoxide Thrombotic Tendency Cholesteryl Ester Hydrolase Activity Ester Hydrolase Activity
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