Summary of Workshop 2b: Lipid-Membrane Interactions of Platelets and Coagulation with the Arterial Wall

  • J. Bryan Smith
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 104)


Both platelets and the arterial wall contain enzymes capable of converting arachidonic acid into the prostaglandin endoperoxides, PGG2 and PGH2. These endoperoxides are subsequently metabolized in platelets into thromboxane A2 which causes platelet aggregation and is a potent vasoconstrictor. By contrast, the endoperoxides are converted in the arterial wall into prostacyclin, a potent inhibitor of platelet aggregation and vasodilator. In the presence of isomerases, the endoperoxides are converted into PGE2 or PGD2.


Cholesteryl Ester Hydrolase Prostaglandin Endoperoxide Thrombotic Tendency Cholesteryl Ester Hydrolase Activity Ester Hydrolase Activity 
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Dr. Gerrard

  1. Gerrard, J.M., Townsend, D., Stoddard, S. Witkop, C.J., and White, J.G. (1977) Am. J. Pathol. 86, 99–116.PubMedGoogle Scholar
  2. Gerrard, J.M., White, J.G., Rao, G.H.R., and Townsend, D. (1976) Am. J. Pathol. 83, 283–298.PubMedGoogle Scholar
  3. Glass, D.B., Gerrard, J.M., Townsend, D., Carr, D.W., White, J.G., and Goldberg, N.D. (1977) J. Cyclic Nucl. Res. 3, 37–94.Google Scholar
  4. Gerrard, J.H., White J.G., and Peterson, D.A. Thrombosis and Hemostasis. In press.Google Scholar

Dr. Mills

  1. Mills, D.C.B., and Smith, J.B. (1971) Biochem. J. 121, 185–188.PubMedGoogle Scholar
  2. Mills, D.C.B., and Smith, J.B. (1972) Ann. N.Y. Acad. Sci. USA 201, 391–396.CrossRefGoogle Scholar
  3. Mills, D.C.B., and Macfarlane, D.E. (1974) Throm. Res. 5, 401–408.CrossRefGoogle Scholar
  4. Mills, D.C.B., Macfarlane, D.E., and Nicolaou, K. (1977) Blood 50, Suppl. 247, Abstract No. 517.Google Scholar

Dr. Ramwell

  1. Uzunova, A.D., Ramey, E.R., and Ramwell, P.W. (1977) Prostaglandins 13, 995–1002.PubMedCrossRefGoogle Scholar
  2. Uzunova, A. Ramey, E., and Ramwell, P.W. (1976) Nature 261, 712–713.PubMedCrossRefGoogle Scholar
  3. Johnson, M., Ramey, E., and Ramwell, P.W. (1975) Nature 253, 355–357.PubMedCrossRefGoogle Scholar
  4. Uzunova, A.D., Ramey, E.R., and Ramwell, P.W. Gonadal Hormones and Pathogenesis of Occlusive Arterial Thrombosis. In press.Google Scholar

Dr. Subbiah

  1. Subbiah, M.T., and Dicke, B.A. (1977) Atherosclerosis 27, 107–111.PubMedCrossRefGoogle Scholar
  2. Subbiah, M.T. (1977) Sixth Int. Symp. on Drugs Affecting Lipid Metabolism, Aug. 29-Sept. 1, 1977, Philadelphia, Pa. In press.Google Scholar

Dr. Hornstra

  1. Hornstra, G., and Haddeman, E. (1977) Thromb. Haem. 38, 19.Google Scholar
  2. Hornstra, G. (1977) Thromb. Haem. 38, 256.Google Scholar
  3. Hornstra, G., Haddeman, E., and Don, J.A. (1977) Thromb. Res. In press.Google Scholar

Copyright information

© Plenum Press, New York 1978

Authors and Affiliations

  • J. Bryan Smith
    • 1
  1. 1.Cardeza Foundation Department of PharmacologyThomas Jefferson UniversityPhiladelphiaUSA

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