Summary of Workshop 2a: Lipid-Membrane Interactions of Platelets and Coagulation
This workshop centered attention on approaches to an understanding of lipid interactions in biological systems. To this end, the topics for discussion focused on the behavior of phospholipids in the intrinsic coagulation process, the mechanism of exchange of cholesterol between vascular compartments and constituents, and the manner in which the lipid exchange proteins can be employed as membrane probes. In order to fully understand the complexities of lipid biochemistry in situ, one must know first about the behavior of purified cell components or comparable model substances in in vitro systems and then armed with this information to investigate their characteristics in the intact cell. Hence, it was the intent of this workshop to illustrate how the first part of this two pronged objective may be accomplished.
KeywordsCholesterol Pyrene Thrombin Ghost Phosphatidylcholine
Unable to display preview. Download preview PDF.
- 1.Barton, P.D. (1975) in Platelets, Drugs, Thromb., Proc. Symp. (Hirsh, J., Cade, J.F., Gallus, A.S. and Schonbaum, E., Eds.), Karger Publ., Basel, pp. 43–48.Google Scholar
- 2.Sterzing, P.R., and Barton, P.G. (1973) Chem. Phys. Lipids 10, 137–148.Google Scholar
- 4.Kao, Y.J., Charlton, S.C. and Smith, L.C. (1977) Fed. Proc. 36, 936 (abstract).Google Scholar