Atherogenesis: The Process from Normal to Lesion
Arteriosclerosis is an ancient lesion found in mummies, illustrated by da Vinci and only clearly designated as a disease distinct from aging processes early in this century. (1, 2) The modern period of research, that is, since about 1930, has seen a progressive emphasis on two major theories of atherogenesis.
KeywordsLipid Accumulation Fatty Streak Arterial Smooth Muscle Cell Major Theory Endothelial Integrity
Unable to display preview. Download preview PDF.
- 1.Long, E.R. (1967) A Survey of the Problem, Cowdry’s Atherosclerosis, 2nd Ed. (Blumenthal, H.T., Ed.), Thomas, Springfield, Ill., pp. 5–20.Google Scholar
- 2.Lebowitz, J.O. (1970) The History of Coronary Heart Disease The Univ. of California Press, Berkeley and Los Angeles.Google Scholar
- 3.Ross, R., and Glomset, J.A. (1976) N. Engl. J. Med. 295, 369–377, 420–425.Google Scholar
- 5.Wolinsky, H. (1976) Cardiovasc. Med., September, 41–54.Google Scholar
- 6.McGill, H.C., Jr. (Paoletti, R. and Gotto, A.M., Jr., Eds.) (1977) in Atherosclerosis Reviews, Vol. 2.Google Scholar
- 9.Benditt, E.P. (1977) Sci. Am., February, 74–85.Google Scholar
- 11.Thomas, W.A., Janakidevi, K., Reiner, J.M., and Lee, K.T. (1976) Circulation 54, No. 4, October II-137, abstract no. 0540.Google Scholar
- 13.Osborn, G.R. (1973) The Incubation Period of Coronary Thrombosis, Butterworths, London.Google Scholar
- 17.McMillan, G.C., and Duff, G.L. (1948) Arch. Pathol. 46, 179–182.Google Scholar