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Activation of the Complement System

  • Neil R. Cooper

Abstract

The complement system is a mediator of a number of biologically important reactions which range from cytotoxicity of antibody-sensitized cells, bacteria, and viruses to mediation of inflammatory processes. The components of the system are a number of normal serum proteins which are present in the circulation as functionally inactive precursor molecules. Activation is the term applied to the process which enables these proteins to participate in a complement reaction. Activation is not a single event, rather it is a dynamic process, as each component must be activated under appropriate conditions in a certain sequence in order to sustain an ongoing complement reaction.

Keywords

Alternate Pathway Complement System Hemolytic Activity Complement Component Paroxysmal Nocturnal Hemoglobinuria 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1973

Authors and Affiliations

  • Neil R. Cooper
    • 1
  1. 1.Department of Experimental PathologyScripps Clinic and Research FoundationLa JollaUSA

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