Norepinephrine, Dopamine and Serotonin: CNS Distribution, Biosynthesis and Metabolism

  • Robert O. Friedel
Part of the Advances in Behavioral Biology book series (ABBI, volume 6)


At the present time the bulk of experimental data relating biochemical factors to certain disorders of human behavior is converging in support of hypotheses implicating the biogenic amines norepinephrine (NE), dopamine (DA), and serotonin (5-HT). The theoretical importance of these substances depends on their putative role as CNS neurotransmitters involved in the central control of a variety of functions ranging from postural tone and appetite to sleep and feeling states. It is felt currently that an understanding of the biochemical etiology and the pharmacological treatment of mental disorders depends on the clarification of the related alterations in the distribution, synthesis, and metabolism of these monoamines. Our basic knowledge of CNS monoamines has increased greatly over the past twenty years, but is still incomplete. This chapter is a selective presentation of the major concepts currently advanced in this area.


Medial Forebrain Bundle Nucleus Reticularis Lateralis Lateral Funiculus Limbic Forebrain Preganglionic Sympathetic Nerve Cell 


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Dahlström, A., and Fuxe, K.: Evidence for the existence of monoamine-containing neurons in the central nervous system. Acta. Physiol. Scand. 62:Suppl. 232: 1–55, 1964.Google Scholar
  2. 2.
    Axelrod, J.: Brain monoamines: biosynthesis and fate. Neuro-sciences Res. Prog. Bull. 9:188–196, March, 1971.Google Scholar

Copyright information

© Plenum Press, New York 1973

Authors and Affiliations

  • Robert O. Friedel

There are no affiliations available

Personalised recommendations