Factors Involved in the Altered Phosphate Reabsorption During Phosphate Loading in Thyroparathyroidectomized Rats
Several investigators (3,4,5,9) observed a decline of renal phosphate reabsorption after prolonged intravenous infusion of phosphate. Similarily high phosphate diets are known to produce phosphaturia and phosphate depletion enhances renal phosphate reabsorption (11,12). The decline of renal phosphate reabsorption during acute or chronic phosphate loading was demonstrated in both, intact and thyroparathyroidectomized (TPTX) rats. Irrespective of the potentially different mechanisms involved in acute and chronic phosphate loading, the kidney appears to be capable to adjust phosphate reabsorption to phosphate input even in the absence of parathyroid hormone.
KeywordsUrinary Flow Rate Plasma Calcium Renal Phosphate Phosphate Reabsorption Plasma Phosphate
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