Attempts to Demonstrate Phosphate Secretion in the Rat
The renal tubular secretion of phosphate from peritubular capillary blood into the tubular lumen has been conclusively demonstrated in some non-mammalian kidneys, yet the presence of such a pathway in the mammalian kidney is still in question (1–9). It is generally agreed that, in the mammalian kidney, the reabsorption of phosphate filtered at the glomerulus is the predominant transport process. Recent studies in man, dog and rat, however, have reopened the question of the existence of a phosphate secretory mechanism (7–9). The current investigations were designed to re-examine this question, utilizing a modification of the precession technique.
KeywordsParathyroid Hormone Left Kidney Proximal Convoluted Tubule Phosphate Excretion Spiny Dogfish
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