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Effects of 1,25-Dihydroxycholecalciferol on Serum Calcium, Phosphate, and Immunoreactive Parathyroid Hormone in Dogs

  • S. B. Oldham
  • R. Smith
  • D. L. Hartenbower
  • H. L. Henry
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 103)

Abstract

Parathyroid hormone (PTH) has been shown to stimulate the formation of 1,25-dihydroxycholecalciferol (1,25(OH)2D3), the most biologically active form of vitamin D3, by the kidney (1, 2). It has been postulated that 1,25(OH)2D3 or other vitamin D3 metabolites might directly influence the secretion of PTH. Receptors for 1,25(OH)2D3 have been identified in chick (3) and pig (4) parathyroid glands and in human parathyroid adenoma (5). Accumulation of 1,25(OH)2D3 by the parathyroid gland has been reported in the chick (6), and 1,25(OH)2D3 when administered to-gether with 24,25-dihydroxycholecalciferol (24,25(OH)2D3), caused the size of the parathyroid glands in vitamin D-deficient chicks to regress (7). The effect of vitamin D metabolites on PTH secretion has been examined in several species. Studies several years ago by Oldham, et al, showed that the administration of pharmacological amounts of 25-hydroxycholecalciferol (250H D3) to vitamin D-deficient dogs appeared to decrease the circulating concentrations of immunoreactive parathyroid hormone (IPTH) before significant increases in serum calcium concentration occurred (8). Chertow, et al, reported a decrease in IPTH in rats administered 1,25(OH)2D3 and an inhibition of IPTH released from slices of bovine parathyroid tissue in vitro when 1,25(OH)2D3 was added to the culture medium (9).

Keywords

Serum Calcium Parathyroid Gland Malachite Green Serum Calcium Concentration Serum IPTH 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    De Luca, H.F. and Schnoes, H.K., “Metabolism and Mechanism of Action of Vitamin D”, Ann. Rev. Biochem. 45: 631, 1976.CrossRefGoogle Scholar
  2. 2.
    Norman, A.W. and Henry, H., “1,25-Dihydroxycholecalciferol - A Hormonally Active Form of Vitamin D”, Rec. Prog. Norm. Res. 30: 431, 1974.Google Scholar
  3. 3.
    Brumbaugh, P.F., Hughes, M.R. and Haussier, M.R., “Cytoplasmic and Nuclear Binding Components for lα,25-dihydroxyvitamin D3 in Chick Parathyroid Glands”, Proc. Nat. Acad. Sci. USA 72: 4871, 1975.PubMedCrossRefGoogle Scholar
  4. 4.
    Cloix, J.F., Ulmann, A., Bachelet, M. and Funck-Brentano, J. L., “Cholecalciferol Metabolites Binding in Porcine Parathyroid Glands”, Steroids 28: 743, 1976.PubMedCrossRefGoogle Scholar
  5. 5.
    Haddad, J.G., Walgate, J., Min, C. and Hahn, T.J., “Vitamin D Metabolite-Binding Proteins in Human Tissue”, Biochim. Biophys. Acta 444: 921, 1976.PubMedCrossRefGoogle Scholar
  6. 6.
    Henry, H.L. and Norman, A.W., “Studies on the Mechanism of Action of Calciferol. VII. Localization of 1,25-DihydroxyVitamin D3 in Chick Parathyroid Glands”, Biochem. Biophys. Res. Commun. 62: 781, 1975.Google Scholar
  7. 7.
    Henry, H.L., Taylor, A.N. and Norman, A.W., “Effect of the Vitamin D Metabolites, 1,25-Dihydroxyvitamin D3 and 24,25-Di-hydroxyvitamin D3 on Chick Parathyroid Gland Size”, J. Nutr. in press.Google Scholar
  8. 8.
    Oldham, S.B., Arnaud, C.D., Jowsey, J., “The Influence of Vitamin D on the Parathyroid”, in Endocrinology, 1973, Taylor, S., Ed., L. Heinemann, London, 1974, p. 261.Google Scholar
  9. 9.
    Chertow, B.S., Baylink, D.J., Wergedal, J.E., Su, M.H.H., and Norman, A.W., “Decrease in Serum Immunoreactive Parathyroid Hormone in Rats and in Parathyroid Secretion in vitro by 1, 25-Dihydroxycholecalciferol”, J. Clin. Invest. 56: 668 1975.PubMedCrossRefGoogle Scholar
  10. 10.
    Canterbury, J.M., Claflin, A.J., Lerman, S., Henry, H.L., Norman, A.W., and Reiss, E., “In Vivo Effects of Vitamin D3 Metabolites on Parathyroid Hormóne PTH) Secretion”, The Endocrine Society, 58th Annual Meeting, 1976, pg. 65.Google Scholar
  11. 11.
    Care, A.D., Bates, R.F.L., Pickard, D.W., Peacock, M., Tomlinson, S., O’Riordan, J.L.H., Mawer, E.B., Taylor, C.M., De Luca, H.F., and Norman, A.W., “The Effects of Vitamin D Metabolites and Their Analogues on the Secretion of Parathyroid Hormone”, Calc. Tiss. Res. 21 (S): 142, 1976.CrossRefGoogle Scholar
  12. 12.
    Llach, F., Coburn, J.W., Brickman, A.S., Kurokawa, K., Norman, A.W., Canterbury, J.M., and Reiss, E., “Acute Actions of 1,25-Dihydroxy-Vitamin D3 in Normal Man: Effect on Calcium and Parathyroid Status”, J. Clin. Endocrinol. Metab., 1977, in press.Google Scholar
  13. 13.
    Kelly, P.J., “Bone Remodeling in Puppies with Experimental Rickets”, J. Lab. Clin. Med. 70: 94, 1967.PubMedGoogle Scholar
  14. 14.
    Arnaud, C.D., Tsao, H.S., and Littledike, T., “Radioimmunoassay of Human Parathyroid Hormone in Serum”, J. Clin. Invest. 56: 21, 1971.CrossRefGoogle Scholar
  15. 15.
    Hohenwallner, W. and Wimmer, E., “The Malachite Green Micro-method for the Determination of Inorganic Phosphate”, Clin. Chim. Acta 45: 169, 1973.PubMedCrossRefGoogle Scholar
  16. 16.
    Fischer, J.A., Hunziker, W., and Dambacher, M., “Distribution of Circulating Parathyroid Hormone Forms in Normal Subjects and in Patients with Hyperparathyroidism”, Clin. Res. 25: 390A, 1977.Google Scholar
  17. 17.
    Fischer, J.A., Binswanger, U., Fanconi, A., Illig, R., Baerlocher, K., and Prader, A., “Serum Parathyroid Hormone Concentrations in Vitamin D Deficiency Rickets of Infancy: Effects of Intravenous Calcium and Vitamin D”, Horm. Metab. Res. 5: 381, 1973.PubMedCrossRefGoogle Scholar
  18. 18.
    Lumb, G.A. and Stanbury, S.W., “Parathyroid Function in Human Vitamin D Deficiency and Vitamin D Deficiency in Primary Hyperparathyroidism”, Amer. J. Med. 56: 833, 1974.PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1978

Authors and Affiliations

  • S. B. Oldham
    • 1
    • 2
    • 3
    • 4
  • R. Smith
    • 1
    • 2
    • 3
    • 4
  • D. L. Hartenbower
    • 1
    • 2
    • 3
    • 4
  • H. L. Henry
    • 1
    • 2
    • 3
    • 4
  1. 1.Depts Med & BiochemUSC Sch MedUSA
  2. 2.VA Wadsworth Hosp CtrUSA
  3. 3.Dept MedUCLA Sch MedUSA
  4. 4.Dept BiochemUC RiversideUSA

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