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Effects of Parathyroid Hormone and Dietary Phosphorus on the Decreased Synthesis of 1,25-Dihydroxyvitamin D3 in Rats with Graded Reduction of Nephron Mass

  • Y. Kawaguchi
  • Y. Kimura
  • M. Yamamoto
  • N. Imamura
  • T. Endo
  • N. Horiuchi
  • T. Suda
  • S. Sakai
  • Y. Ogura
  • Y. Ueda
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 103)

Abstract

Kidney plays a critical role for the metabolism of vitamin D3 by converting 25-hydroxy-cholecalciferol (25-OH-D3) to 1,25-dihydroxycholecalciferol (1,25-(OH)2-D3), an active metabolite of the vitamin. It has been suggested that the altered vitamin D metabolism is a major factor for the pathogenesis of renal osteodystrophy. Nevertheless, little data are available regarding the production of 1,25-(OH)2-D3 in chronic renal failure. We studied the effects of graded reduction of nephron mass on the renal conversion of 25-(OH)-D3 to 1,25-(OH)2-D3 in rats. Furthermore, the roles played by parathyroid hormone and phosphorus on renal production of 1,25-(OH)2-D3 in experimental renal failure were evaluated.

Keywords

Parathyroid Hormone Chronic Renal Failure Renal Mass Renal Osteodystrophy Chronic Experiment 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Bligh, E.G. and Dyer, W.J.: A rapid method of total lipid extraction and purification, Canad. J. Biochem. Physiol. 37; 911, 1957.CrossRefGoogle Scholar
  2. 2.
    Holick, M.F. and DeLuca, H.F.: A new chromatographic technique for vitamin D3 metabolite. J. Lipid Res. 12; 460, 1971.PubMedGoogle Scholar

Copyright information

© Plenum Press, New York 1978

Authors and Affiliations

  • Y. Kawaguchi
    • 1
    • 2
  • Y. Kimura
    • 1
    • 2
  • M. Yamamoto
    • 1
    • 2
  • N. Imamura
    • 1
    • 2
  • T. Endo
    • 1
    • 2
  • N. Horiuchi
    • 1
    • 2
  • T. Suda
    • 1
    • 2
  • S. Sakai
    • 1
    • 2
  • Y. Ogura
    • 1
    • 2
  • Y. Ueda
    • 1
    • 2
  1. 1.Department of MedicineTokyo Jikei-Kai UniversityJapan
  2. 2.Department of BiochemistryTokyo Medical and Dental UniversityTokyoJapan

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