Abstract
Kidney plays a critical role for the metabolism of vitamin D3 by converting 25-hydroxy-cholecalciferol (25-OH-D3) to 1,25-dihydroxycholecalciferol (1,25-(OH)2-D3), an active metabolite of the vitamin. It has been suggested that the altered vitamin D metabolism is a major factor for the pathogenesis of renal osteodystrophy. Nevertheless, little data are available regarding the production of 1,25-(OH)2-D3 in chronic renal failure. We studied the effects of graded reduction of nephron mass on the renal conversion of 25-(OH)-D3 to 1,25-(OH)2-D3 in rats. Furthermore, the roles played by parathyroid hormone and phosphorus on renal production of 1,25-(OH)2-D3 in experimental renal failure were evaluated.
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References
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Holick, M.F. and DeLuca, H.F.: A new chromatographic technique for vitamin D3 metabolite. J. Lipid Res. 12; 460, 1971.
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© 1978 Plenum Press, New York
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Kawaguchi, Y. et al. (1978). Effects of Parathyroid Hormone and Dietary Phosphorus on the Decreased Synthesis of 1,25-Dihydroxyvitamin D3 in Rats with Graded Reduction of Nephron Mass. In: Massry, S.G., Ritz, E., Rapado, A. (eds) Homeostasis of Phosphate and Other Minerals. Advances in Experimental Medicine and Biology, vol 103. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-7758-0_50
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DOI: https://doi.org/10.1007/978-1-4684-7758-0_50
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4684-7760-3
Online ISBN: 978-1-4684-7758-0
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