Effects of Parathyroid Hormone and Dietary Phosphorus on the Decreased Synthesis of 1,25-Dihydroxyvitamin D3 in Rats with Graded Reduction of Nephron Mass
Kidney plays a critical role for the metabolism of vitamin D3 by converting 25-hydroxy-cholecalciferol (25-OH-D3) to 1,25-dihydroxycholecalciferol (1,25-(OH)2-D3), an active metabolite of the vitamin. It has been suggested that the altered vitamin D metabolism is a major factor for the pathogenesis of renal osteodystrophy. Nevertheless, little data are available regarding the production of 1,25-(OH)2-D3 in chronic renal failure. We studied the effects of graded reduction of nephron mass on the renal conversion of 25-(OH)-D3 to 1,25-(OH)2-D3 in rats. Furthermore, the roles played by parathyroid hormone and phosphorus on renal production of 1,25-(OH)2-D3 in experimental renal failure were evaluated.
KeywordsParathyroid Hormone Chronic Renal Failure Renal Mass Renal Osteodystrophy Chronic Experiment
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