Pathogenesis of Renal Osteodystrophy: Roles of Phosphate and Skeletal Resistance to PTH

  • E. Ritz
  • H. H. Malluche
  • B. Krempien
  • W. Tschope
  • S. G. Massry
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 103)


The different pathogenetic mechanisms responsible for uremic bone disease are still not fully understood. However, as some of the factors involved in the development of renal osteodystrophy have been clarified, it became apparent that abnormalities in phosphate homeostasis play an important role in the control of PTH secretion and in modifying the skeletal response to PTH.


Secondary Hyperparathyroidism Renal Osteodystrophy Tubular Basement Membrane Phosphate Homeostasis Osteitis Fibrosa 


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Copyright information

© Plenum Press, New York 1978

Authors and Affiliations

  • E. Ritz
    • 1
  • H. H. Malluche
    • 2
  • B. Krempien
    • 1
  • W. Tschope
    • 1
  • S. G. Massry
    • 2
  1. 1.Dept. Int. Med. and PathologyUniv. of HeidelbergHeidelbergGermany
  2. 2.Div. NephrologyLAC/USC Medical CenterLos AngelesUSA

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