Renal Tubular Phosphate Reabsorption in the Phosphate Depleted Dog
Phosphate depletion has been shown to produce a variety of alterations in renal tubular function. Filtered phosphate is avidly reabsorbed, and the phosphaturic responses to volume expansion, parathyroid hormone and bicarbonate infusion are diminished or abolished (1,2). Renal tubular reabsorption of calcium (3) is impaired, leading to impressive hypercalciuria, and evidence has been presented which suggests that phosphate depletion is associated with impairment of tubular glucose (4) and bicarbonate (5) reabsorption, and alteration of proximal fluid reabsorption (6).
KeywordsDistal Tubule Renal Tubular Reabsorption Renal Tubular Function Phosphate Depletion Fractional Reabsorption
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- 1.Wen, S.F. Phosphate transport in the phosphate-depleted dog. Abstracts 8th Annual Meeting of American Society of Nephrology, p. 9, 1975.Google Scholar
- 4.Gold, L.W., Massry, S.G. and Friedler, R.M. Effect of phosphate depletion on renal tubular reabsorption of glucose. J. Lab. Med. 89: 554, 1977.Google Scholar