The Effects of Phosphate Depletion on Bone
The importance of phosphate in the metabolism of an organism has been indicated by many of the other papers in this volume. Since phosphate is a major constituent of the mineralized phase of bone, this tissue can function as a reservoir for maintaining the extracellular fluid phosphate concentration during a period of phosphate depletion. In young, growing animals phosphate depletion results in decreased growth in general and decreased length of the long bones (1). Several workers have also shown that phosphate depletion results in an increased resorption of bone (1–3).
KeywordsBone Resorption Serum Phosphate Resorptive Activity Osteoclast Number Total Serum Calcium
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- 2.Day, H.G., and McCollum, E.V.: Mineral metabolism, growth, and symptomatology of rats on a diet extremely deficient in phosphorus. J. Biol. Chem. 130: 269, 1939.Google Scholar
- 6.Baylink, D., Wergedal, J., Stauffer, M., and Rich, C.: Effects of fluoride on bone formation, mineralization, and resorption in the rat. In Fluoride in Medicine. T. L. Vischer, editor. Hans Huber, Bern. 37, 1970.Google Scholar
- 9.Haussler, M., Hughes, M., Baylink, D., Littledike, E.T., Cork, D., and Pitt, M.: Influence of phosphate depletion on the biosynthesis and circulating level of la,25-dihydroxyvitamin D. In Phosphate Metabolism. S. G. Massry and E. Ritz, editors. Plenum Press, New York. 233, 1977.Google Scholar
- 11.Ivey, J.L., Su, M., Feist, E., and Baylink, D.: Phosphate and vitamin D status on serum PTH in rats. Program and Abstracts of the 59th Annual Meeting of The Endocrine Society. 310, 1977.Google Scholar