Abstract
The importance of phosphate in the metabolism of an organism has been indicated by many of the other papers in this volume. Since phosphate is a major constituent of the mineralized phase of bone, this tissue can function as a reservoir for maintaining the extracellular fluid phosphate concentration during a period of phosphate depletion. In young, growing animals phosphate depletion results in decreased growth in general and decreased length of the long bones (1). Several workers have also shown that phosphate depletion results in an increased resorption of bone (1–3).
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References
Baylink, D., Wergedal, J., and Stauffer, M.: Formation, mineralization, and resorption of bone in hypophosphatemic rats. J. Clin. Invest. 50: 2519, 1971.
Day, H.G., and McCollum, E.V.: Mineral metabolism, growth, and symptomatology of rats on a diet extremely deficient in phosphorus. J. Biol. Chem. 130: 269, 1939.
Raisz, L.G., and Niemann, I.: Effect of phosphate, calcium, and magnesium on bone resorption and hormonal responses in tissue culture. Endocrinology. 85: 446, 1969.
Wergedal, J.: Enzymes of protein and phosphate catabolism in rat bone. I. Enyzme properties in normal rats. Calcified Tissue Res. 3: 55, 1969.
Baylink, D., Wergedal, J., Stauffer, M., and Rich, C.: Formation, mineralization, and resorption of bone in vitamin D-Deficient rats. J. Clin. Invest. 49: 1122, 1970.
Baylink, D., Wergedal, J., Stauffer, M., and Rich, C.: Effects of fluoride on bone formation, mineralization, and resorption in the rat. In Fluoride in Medicine. T. L. Vischer, editor. Hans Huber, Bern. 37, 1970.
Baylink, D., Morey, E., and Rich, C.: Effect of calcitonin on the rates of bone formation and resorption in the rat. Endocrinology. 84: 261, 1969.
Thompson, E., Baylink, D., and Wergedal, J.: Increases in number and size of osteoclasts in response to calcium or phosphorus deficiency in the rat. Endocrinology. 97: 283, 1975.
Haussler, M., Hughes, M., Baylink, D., Littledike, E.T., Cork, D., and Pitt, M.: Influence of phosphate depletion on the biosynthesis and circulating level of la,25-dihydroxyvitamin D. In Phosphate Metabolism. S. G. Massry and E. Ritz, editors. Plenum Press, New York. 233, 1977.
Bruin, W.J., Baylink, D.J., and Wergedal, J.E.: Acute inhibition of mineralization and stimulation of bone resorption mediated by hypophosphatemia. Endocrinology. 96: 394, 1975.
Ivey, J.L., Su, M., Feist, E., and Baylink, D.: Phosphate and vitamin D status on serum PTH in rats. Program and Abstracts of the 59th Annual Meeting of The Endocrine Society. 310, 1977.
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© 1978 Plenum Press, New York
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Ivey, J.L., Morey, E.R., Baylink, D.J. (1978). The Effects of Phosphate Depletion on Bone. In: Massry, S.G., Ritz, E., Rapado, A. (eds) Homeostasis of Phosphate and Other Minerals. Advances in Experimental Medicine and Biology, vol 103. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-7758-0_38
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DOI: https://doi.org/10.1007/978-1-4684-7758-0_38
Publisher Name: Springer, Boston, MA
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