Skeletal Muscle in Hypophosphatemia and Phosphorus Deficiency

  • James P. Knochel
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 103)


The intentions of this presentation are to briefly review the clinical characteristics of acute rhabdomyolysis with hypophosphatemia; how this syndrome differs from the chronic hypophosphatemic myopathy and to provide a brief overview of our recent clinical and experimental work concerning cellular injury in phosphorus deficiency and hypophosphatemia.


Serum Phosphorus Magnesium Deficiency Chronic Alcoholism Respiratory Alkalosis Phosphorus Deficiency 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Knochel, J.P., Bilbrey, G.L., Fuller, T.J. and Carter, N.W.: The muscle cell in chronic alcoholism: The possible role of phosphate depletion in alcoholic myopathy. Annals NY Academy Sci 252: 274–286, 1975.CrossRefGoogle Scholar
  2. 2.
    Knochel, J.P.: The pathophysiology and clinical characteristics of severe hypophosphatemia. Arch Int Med 137: 203–220, 1977.CrossRefGoogle Scholar
  3. 3.
    Ravid, M. and Robson, M.: Proximal myopathy caused by iatrogenic phosphate depletion. JAMA 236: 1380–1381, 1976.Google Scholar
  4. 4.
    Fordtran, J.: Personal communication, 1976.Google Scholar
  5. 5.
    Anast, C.S., Mohs, J.M., Kaplan, S.L., et al.: Evidence for parathyroid failure in magnesium deficiency. Science 177: 606–608, 1972.PubMedCrossRefGoogle Scholar
  6. 6.
    Matter, B.J., Worona, M., Donat, P. et al: Effect of ethanol on phosphate excretion in man. Clin Res 12: 255, 1964.Google Scholar
  7. 7.
    Knochel, J.P., Cohen, M., Anderson, R., Carter, N., Cotton, J. and Elms, J. Muscle composition in alcoholic myopathy. Clin Res 24: 589A, 1976.Google Scholar
  8. 8.
    Velentizas, C., Oreopoulos, D.G., Brandes, L., Wilson, D.R., Marquez-Julio, A.: Abnormal vitamin-D levels in alcoholics. Annals Int Med 86: 198, 1977.Google Scholar
  9. 9.
    Cohen, S.L., Maclntryre, I., Grahame-Smith, D. and Walker, J. S.: Alcohol-stimulated calcitonin release in medullary carcinoma of the thyroid. Lancet 1172–1174, 1973.Google Scholar
  10. 10.
    Tanzer, F.S. and Navia, J.M.: Calcitonin inhibition of intestinal phosphate absorption. Nature New Biology 242: 221–222, 1973.Google Scholar
  11. 11.
    Ardaillou, R., Fallastre, J.P., Milhaud, G., Rosselet, F., Delaunay, F. and Richet, G. Renal excretion of phosphate, calcium and sodium during and after a prolonged thyrocalcitonin infusion in man.Google Scholar
  12. 12.
    Won Lee, S., Russell, J. and Avioli, LV: 25-Hydroxycholecalciferol to 1,25-Dihydroxycholecaciferol: conversion impaired by systemic metabolic acidosis. Science 195: 994–995, 1977.Google Scholar
  13. 13.
    Schneider, L.E. and Schedl, H.P.: Experimental diabetes reduces circulating 1,25-dihydroxyvitamin D in the rat. Science 196: 1452–1453, 1977.PubMedCrossRefGoogle Scholar
  14. 14.
    Woods, H.F., Eggleston, L.V. and Krebs, H.A.: The cause of hepatic accumulation of fructose 1-phosphate on fructose loading. Biochem J 119: 501–510, 1970.PubMedGoogle Scholar
  15. 15.
    Craig, W.M. and Crane, C.W.: Lactic acidosis complicating liver failure after intravenous fructose. Br Med J 4: 21 1212, 1971.Google Scholar
  16. 16.
    Farber, F: ATP and cell integrity. Fed Proc 32: 1534 1539, 1973.Google Scholar
  17. 17.
    Sweetin, J.C. and Thomson, W.H.S.: Enzyme efflux and clearance. Clinica Chimica Acta 48: 403–411, 1973.CrossRefGoogle Scholar
  18. 18.
    Danowski, T.S., Gillespie, H.K., Fergus, E.B. et al: Significance of blood sugar and serum electrolyte changes in cirrhosis following glucose, insulin, glucagon or epinephrine. Yale J Biol Med 29: 361–375, 1957.Google Scholar
  19. 19.
    Harter, H.R., Santiago, J.V., Rutherford, W.E., Slatopolsky, E. and Klahr, S.: The relative roles of calcium, phosphorus and parathyroid hormone in glucose and tolbutamide-mediated insulin release. J Clin Invest 58: 359–367, 1976.PubMedCrossRefGoogle Scholar
  20. 20.
    Fuller, T.J., Carter, N.W., Barcenas, C. and Knochel, J.P.: Reversible changes of the muscle cell in experimental phosphorus deficiency. J Clin Invest 57: 1019–1024, 1976.PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1978

Authors and Affiliations

  • James P. Knochel
    • 1
    • 2
  1. 1.Renal SectionVA HospitalDallasUSA
  2. 2.University of Texas Medical SchoolUSA

Personalised recommendations