The Hypocalcemia of Magnesium Depletion

  • E. Slatopolsky
  • R. Rosenbaum
  • P. Mennes
  • S. Klahr
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 103)


Hypocalcemia has been observed in conjunction with severe magnesium depletion (1–8). This association is seen mainly in pathological conditions characterized by decreased absorption of magnesium from the gastrointestinal tract. The postulate that the hypocalcemia is the consequence of magnesium deficiency per se, and not calcium deficiency, is supported by studies showing that this syndrome can be reproduced by restricting magnesium in the diet or that hypocalcemia can be corrected by replacing magnesium alone without supplementation of calcium and/or vitamin D. The pathogenesis of hypocalcemia in magnesium depletion is multifactorial; however, recent studies have clarified previous controversial results regarding the role of PTH in this syndrome (2–5).


Celiac Disease Parathyroid Hormone Magnesium Deficiency Parathyroid Hormone Secretion Magnesium Depletion 
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Copyright information

© Plenum Press, New York 1978

Authors and Affiliations

  • E. Slatopolsky
    • 1
  • R. Rosenbaum
    • 1
  • P. Mennes
    • 1
  • S. Klahr
    • 1
  1. 1.Department of Medicine, Renal DivisionWashington University School of MedicineSt. LouisUSA

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