Interrelations Between Phosphorus, Calcium, Parathyroid Hormone, and Phosphate Excretion in the Normal and Uremic Dog

  • Michael A. Kaplan
  • Janet M. Canterbury
  • George Gavellas
  • Eric Reiss
  • Neal S. Bricker
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 103)


Phosphorus homeostasis is maintained in animals and man by excretion through the kidneys of the same amount of phosphorus absorbed from the intestines on an ongoing basis. There is apparently little impairment of gastrointestinal phosphorus absorption in uremia (1); yet phosphorus balance is well maintained in animals and man with advancing chronic renal disease. This balance is accomplished by progressive increases in fractional excretion of phosphate (\((F{{E}_{P{{O}_{4}}}})\)) by the kidneys and associated increases in para-thyroid hormone (PTH) secretion (2–5).


Parathyroid Hormone Fractional Excretion Serum Phosphorus Phosphate Excretion Renal Tubular Reabsorption 
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Copyright information

© Plenum Press, New York 1978

Authors and Affiliations

  • Michael A. Kaplan
    • 1
  • Janet M. Canterbury
    • 1
  • George Gavellas
    • 1
  • Eric Reiss
    • 1
  • Neal S. Bricker
    • 1
  1. 1.Department of Medicine, Divisions of Nephrology and Endocrinology and Institute for Kidney DiseasesUniversity of Miami School of MedicineMiamiUSA

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