Inadequate Bone Response to Phosphate and Vitamin D in Familial Hypophosphatemic Rickets (FHR)
With the almost complete disappearance of vitamin D deficiency in the North-American continent, most cases of rickets now encountered on the pediatric wards may be attributed to one of the several states of vitamin D resistance. The most common of them is familial hypophosphatemic rickets (FHR) a condition usually transmitted as a sex-linked dominant trait. It is characterized by a hypophosphatemia present at birth, bone changes resembling vitamin D deficiency rickets and growth retardation. Bony deformities of the lower limbs are frequent but myopathy is strikingly absent (1).
KeywordsPhosphate Salt Normal Serum Calcium Resorption Surface Osteoid Surface Osteoblastic Surface
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