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Further Evidence Supporting the Phosphate Leak Hypothesis of Idiopathic Hypercalciuria

  • F. H. Shen
  • J. L. Ivey
  • D. J. Sherrard
  • R. L. Nielsen
  • M. R. Haussler
  • D. J. Baylink
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 103)

Abstract

We have previously reported (1,2) that a group of patients with idiopathic hypercalciuria (IH) exhibited certain metabolic characteristics. Compared with age- and sex-matched control subjects, the IH patients were normocalcemic, but their serum phosphate and immunoreactive parathyroid hormone (PTH) concentrations were lower, serum 1,25-dihydroxyvitamin D (1,25-diOHD) concentration, urinary calcium excretion, and fractional enteral calcium absorption were higher. Even though their serum phosphate concentration was lower than that of the controls, urinary phosphate excretion was normal in the IH patients due to a lower TTP/GFR (2).

Keywords

Serum Phosphate Tubular Reabsorption Serum iPTH Idiopathic Hypercalciuria Phosphate Treatment 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Shen, F., Baylink, D., Nielson, R., Hughes, M, and Haussier, M.: Increased serum 1,25-dihydroxycholecalciferol (1,25diOHD3) in patients with idiopathic hypercalciuria (IH). Clin. Res. 23: 423A, 1975.Google Scholar
  2. 2.
    Shen, F., Baylink, D.J., Nielsen, R.L., Sherrard, D.J., Ivey, J.L., and Haussier, M.R.: Increased serum 1,25-dihydroxyvitamin D in idiopathic hypercalciuria. J Lab. Clin. Med., in press.Google Scholar
  3. 3.
    Dominguez, J.H., Gray, R.W., and Lemann, J., Jr: Dietary phosphate deprivation in women and men: Effects on mineral and acid balances, parathyroid hormone and the metabolism of 25-OH-vitamin D. J. Clin. Endocrinol. Metab. 43: 1056, 1976.PubMedCrossRefGoogle Scholar
  4. 4.
    Chertow, B.S., Baylink, D.J., Wergedal, J.E., Su, M.H.H., and Norman, A.W.: Decrease in serum iPTH in rats and in PTH secretion in vitro by 1,25-dihydroxycholecalciferol. J. Clin. Invest. 56: 668, 1975PubMedCrossRefGoogle Scholar
  5. 5.
    Haussler, M.R., Baylink, D.J., and Hughes, M.R.: The assay of la,25-dihydroxyvitamin D3: Physiologic and pathologic modulation of circulating hormone levels. Clin. Endocrinol. 5: 151s, 1976.Google Scholar
  6. 6.
    Baylink, D., Wergedal, J., and Stauffer, M.: Formation, mineralization, and resorption of bone in hypophosphatemic rats. J. Clin. Invest. 50: 2519, 1971.PubMedCrossRefGoogle Scholar
  7. 7.
    Ivey, J.L., Morey, E.R., Liu, C.-C., Rader, J.I. and Baylink, D.J.: Effects of vitamin D and its metabolites on bone. In Vitamin D: Biochemical, Chemical and Clinical Aspects Related to Calcium Metabolism. A.W. Norman, K. Schaefer, J.W. Coburn, H.F. DeLuca, D. Fraser, H.G. Grigoleit, and D.V. Merrath (Editors). de Gruyter. 349, 1977.Google Scholar
  8. 8.
    Ivey, J.L., Su,M., Feist, E., and Baylink, D.J.: Phosphate and vitamin D status on serum PTH in rats. Program and Abstracts of the 59th Annual Meeting of The Endocrine Society. 310, 1977.Google Scholar
  9. 9.
    Amiel, C., Kuntziger, H., Couette, S., Coureau, C., and Bergounioux, N.: Evidence for a parathyroid hormone-independent calcium modulation of phosphate transport along the nephron. J. Clin. Invest. 57: 256, 1976.PubMedCrossRefGoogle Scholar
  10. 10.
    Brumbaugh, P.F., Haussler, D.H., Bursac, K.M., and Haussler, M.R.: Filter assay for la,25-dihydroxyvitamin D3. Utilization of the hormone’s target tissue chromatin receptor. Biochemistry. 13: 4091, 1974.PubMedCrossRefGoogle Scholar
  11. 11.
    Gilman, A.G.: A protein binding assay for adenosine 3’:5’-cyclic monophosphate. Proc. Natl. Acad. Sci. U.S.A. 67: 305, 1970.PubMedCrossRefGoogle Scholar
  12. 12.
    DeGrazia, J.A., Ivanovich, P., Fellows, H., and Rich, C.: A double isotope method for measurement of intestinal absorpion of calcium in man. J. Lab. Clin. Med. 66: 822, 1965.PubMedGoogle Scholar
  13. 13.
    Pak, C.Y.C., Ohata, M., Lawrence, E.C., et al: The hypercalciurias. Causes, parathyroid functions, and diagnostic criteria. J. Clin. Invest. 54: 387, 1974.PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1978

Authors and Affiliations

  • F. H. Shen
    • 1
    • 2
    • 3
    • 4
    • 5
  • J. L. Ivey
    • 1
    • 2
    • 3
    • 4
    • 5
  • D. J. Sherrard
    • 1
    • 2
    • 3
    • 4
    • 5
  • R. L. Nielsen
    • 1
    • 2
    • 3
    • 4
    • 5
  • M. R. Haussler
    • 1
    • 2
    • 3
    • 4
    • 5
  • D. J. Baylink
    • 1
    • 2
    • 3
    • 4
    • 5
  1. 1.Seattle VA HospitalSeattleUSA
  2. 2.American Lake VA HospitalTacomaUSA
  3. 3.Department of MedicineUniversity of WashingtonSeattleUSA
  4. 4.The Mason ClinicSeattleUSA
  5. 5.Department of BiochemistryCollege of Medicine, University of ArizonaTucsonUSA

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