Vitamin D-Dependent Phosphate Transport by Chick Intestine: Inhibition by Low Na+ and N-Ethylmaleimide

  • Meinrad Peterlik
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 103)


In vitamin D-deficient chicks the duodenum displays a high capacity of phosphate (Pi) transfer from lumen to blood side, while jejunum and ileum show only low rates of transepithelial Pi transport. Vitamin D3 stimulates intestinal phosphate absorption in all parts of the chick small intestine: The increment in Pi absorption due to vitamin D3 is relatively small in the duodenum and also in the ileum. However, in the jejunum the vitamin increases the rate of Pi transfer to a level comparable to that displayed by the duodenum. In the jejunum, entry of Pi from the lumen is by a carrier-mediated energy-dependent transport mechanism presumably located at the brush border. Vitamin D3 enhances the maximal velocity of this process two- to threefold. This effect is probably due to the action of the active metabolite, 1,25-dihydroxy-vitamin D3 The exact mechanism by which the latter stimulates Pi influx is not known at present. However, a protein syntietic step seems to be necessary for enhancement of Pi absorption by the hormonally acting sterol (1, 2, 3).


Phosphate Transport Absorptive Process Mucosal Solution Intestinal Phosphate Absorption Mucosal Border 
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Copyright information

© Plenum Press, New York 1978

Authors and Affiliations

  • Meinrad Peterlik
    • 1
  1. 1.Department of General and Experimental PathologyUniversity of ViennaAustria

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