Outflux of 45Calcium Along the Rat Nephron

  • R. Greger
  • F. Lang
  • H. Oberleithner
  • P. Deetjen
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 103)


From previous micropuncture data (1,4–6,9–15,17,19) it was postulated that calcium is reabsorbed in the proximal tubule and in addition in the distal tubule and/or collecting duct. This was concluded by comparing the amount of calcium present at the distal puncture site and that in final urine. Although this discrepancy between distal and urinary calcium load as detected by free flow micropuncture and clearance techniques might reflect distal reabsorption of calcium, it is no direct prove for that. A similar result might be obtained if there was nephron heterogeneity in regard to calcium reabsorption with the implication that deeper nephrons reabsorb calcium more avidly than superficial ones.


Proximal Tubule Distal Tubule Distal Convoluted Tubule Nephron Segment Calcium Reabsorption 
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  1. 1.
    Agus, Z.S., Gardner, L.B., Beck, L.H., Goldberg, M.: Effects of parathyroid hormone on renal tubular reabsorption of calcium, sodium, and phosphate. Am.J.Physiol. 224, 1143–1148 (1973).PubMedGoogle Scholar
  2. 2.
    Brunette, M., Aras, M.: A microinjection study of nephron permeability to calcium and magnesium. Am.J.Physiol. 221, 1442–1448 (1971).PubMedGoogle Scholar
  3. 3.
    Constanzo,L.S., Windhager, E.E.: Characteristics of calcium transport in the distal convoluted tubule. Kidney Int. 10, 489 (1976)Google Scholar
  4. 4.
    Duarte, C.G., Watson, J.F.: Calcium reabsorption in proximal tubule of the dog nephron: Am.J.Physiol. 212, 1355–1360 (1967)PubMedGoogle Scholar
  5. 5.
    Edwards, B.R., Sutton, R.A.L., Dirks, J.H.: Effect of calcium infusion on renal tubular reabsorption in the dog. Am.J.Physiol. 227, 13–18 (1974)PubMedGoogle Scholar
  6. 6.
    Frick, A., Rumrich, G., Ullrich, K.J., Lassiter, W.E.: Micro-perfusion study of calcium transport in the proximal tubule of the rat kidney. Pflügers Arch. 286, 109–117 (1965)CrossRefGoogle Scholar
  7. 7.
    Greger, R., Lang, F. and Oberleithner, H.: Distal site of calcium reabsorption in the rat kidney. Pflügers Arch. submitted.Google Scholar
  8. 8.
    Jamison, R.L., Frey, N.R., Lacy, F.B.: Calcium reabsorption in the thin loop of Henle. Am.J.Physiol. 227, 745–751 (1974)PubMedGoogle Scholar
  9. 9.
    Kövér, G.: Effect of hypercalcaemia on tubular calcium and phosphate transport. Acta Physiol. Acad. Sci, Hung. 45, 95107 (1974)Google Scholar
  10. 10.
    Kuntzinger, H., Amiel, C., Roinel, N., Morel, F.: Effects of parathyroidectomy and cyclic AMP on renal transport of phosphate, calcium, and magnesium. Am.J.Physiol. 227, 905–911 (1974)Google Scholar
  11. 11.
    Lassiter, W.E., Gottschalk, C.W., Mylle, M.: Micropuncture study of renal tubular reabsorption of calcium in normal rodents. Am.J.Physiol. 204, 771–775 (1963)Google Scholar
  12. 12.
    Le Grimellec, C., Roinel, N., Morel, F.: Simultaneous Mg, Ca, P, K, Na and Cl analysis in rat tubular fluid. III during acute Ca plasma loading. Pflügers Arch. 346, 171–188 (1974)PubMedCrossRefGoogle Scholar
  13. 13.
    Murayama, Y., Morel, F., Le Grimellec, C.: Phosphate, calcium, and magnesium transfers in proximal tubules and loops of Henle, as measured by single nephron microperfusion experiments in the rat. Pflügers Arch. 333, 1–16 (1972)PubMedCrossRefGoogle Scholar
  14. 14.
    Quamme, G.A., Wong, N.L.M., Sutton, R.A.L., Dirks, J.H.: Interrelationships of chlorothiazide and parathyroid hormone: a micropuncture study. Am.J.Physiol. 229, 200–205 (1975)PubMedGoogle Scholar
  15. 15.
    Schneider, E.G., Strandhoy, J.W., Willis, J.R., Knox, F.G.: Relationship between proximal sodium reabsorption and excretion of calcium, magnesium and phosphate. Kidney Int. 4, 369–376 (1973)PubMedCrossRefGoogle Scholar
  16. 16.
    Shirley, D.G., Poujeol, P., Le Grimellec, C.: Phosphate, calcium and magnesium fluxes into lumen of the rat proximal convoluted tubule. Pflügers Arch. 362, 247–254 (1976)PubMedCrossRefGoogle Scholar
  17. 17.
    Sutton, R.A.L., Wong, N.L.M., Dirks, J.H.: Effects of parathyroid hormone on sodium and calcium transport in the dog nephron. Clin. Sci. Mol. Med. 51, 345–351 (1976)PubMedGoogle Scholar
  18. 18.
    Ullrich, K.J., Capasso, G., Rumrich, G., Klöss, S.: Effect of parathyroid hormone on the active Ca2+-reabsorption in the proximal convolution of the rat kidney. Pflügers Arch. 359, R 118 (1975)Google Scholar
  19. 19.
    Ullrich, K., Rumrich, G., Klöss, S.: Acitve Ca2+-reabsorption in the proximal tubule of the rat kidney. Dependence on sodium and buffer transport. Pflügers Arch. 364, 223–228 (1976)PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1978

Authors and Affiliations

  • R. Greger
    • 1
  • F. Lang
    • 1
  • H. Oberleithner
    • 1
  • P. Deetjen
    • 1
  1. 1.Physiologisches InstitutUniversität InnsbruckInnsbruckAustria

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