Importance of 25-Hydroxylation to the Renal Tubular Actions of Vitamin D Metabolites
Experimental observations from my own laboratory as well as data from other workers have documented an acute effect of vitamin D and certain of its metabolites on renal tubular electrolyte transport (1–5). Both in the dog and the rat, the infusion of the biologically active derivative of vitamin D3, 25-hydroxycholecalciferol (25 HCC) and 1,25-dihydroxycholecalciferol (1,25 DHCC) has been demonstrated to produce an acute enhancement of phosphate (1–5), calcium and sodium (4,5) reabsorption. Recently, a series of additional metabolites and analogues has been discovered (6). Their subsequent characterization and synthesis have provided us with the opportunity to study the structural requirements of these vitamin D3 derivatives with regard to their ability to alter renal tubular transport. The protocol utilized for these studies was identical to that originally described (1).
KeywordsEffective Renal Plasma Flow Phosphate Excretion Renal Tubular Transport Allegheny General Hospital Vasopressin Administration
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