Micropuncture Study of Phosphorus Transport in Genetic Hypophosphatemic Mice
Altough hypophosphatemic vitamin D-resistant rickets was first described by Albright and coll. in 1937 (1) the pathogenesis of this disease is still unknown. Two opposing hypothesis exist regarding the primary defect responsible for the constant hypophosphatemia. The first suggests a faulty intestinal absorption of calcium with secondary hyperparathyroidism, whereas the second places the initial responsibility on a defect of renal transport of phosphorus. The measurement of serum immunoreactive PTH has been found normal or low by Rook and coli (9), and by Arnaud (2), slightly increased by Lewy (7), and definitely increased by Reitz (8). Since the hyperparathyroidism is not a constant finding and when present, it seems not pronounced enough to explain the biological trait of the disease the hypothesis of a primary renal defect seems more probable.
KeywordsProximal Tubule Secondary Hyperparathyroidism Serum Parathyroid Hormone Tubular Fluid Micropuncture Study
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