Effect of Volume Expansion on Phosphate Transport in Uremic Dogs
Functional adaptation for renal phosphate transport in chronic renal failure has generally been considered to be mainly the result of secondary hyperparathyroidism (1, 2). On the other hand, it has also been reported that uremic animals can maintain phosphate homeostasis in the absence of parathyroid glands (3). Our present clearance and micropuncture studies were designed to re-evaluate the role of parathyroid hormone (PTH) in phosphate adaptation of uremic remnant kidney dogs.
KeywordsProximal Tubule Parathyroid Gland Secondary Hyperparathyroidism Functional Adaptation Phosphate Transport
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