Advertisement

Effect of Volume Expansion on Phosphate Transport in Uremic Dogs

  • Sung-Feng Wen
  • James W. BoynarJr.
  • Robert W. Stoll
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 103)

Abstract

Functional adaptation for renal phosphate transport in chronic renal failure has generally been considered to be mainly the result of secondary hyperparathyroidism (1, 2). On the other hand, it has also been reported that uremic animals can maintain phosphate homeostasis in the absence of parathyroid glands (3). Our present clearance and micropuncture studies were designed to re-evaluate the role of parathyroid hormone (PTH) in phosphate adaptation of uremic remnant kidney dogs.

Keywords

Proximal Tubule Parathyroid Gland Secondary Hyperparathyroidism Functional Adaptation Phosphate Transport 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Slatopolsky E, Gradowska L, Kashemsant C, Keltner R, Manley C and Bricker NS: The control of phosphate excretion in uremia. J Clin Invest 45: 672, 1966.PubMedCrossRefGoogle Scholar
  2. 2.
    Slatopolsky E, Robson AM, Elkan I and Bricker NS: Control of phosphate excretion in uremic man. J Clin Invest 47: 1865, 1968.PubMedCrossRefGoogle Scholar
  3. 3.
    Swenson RS, Weisinger JR, Ruggeri JL and Reaven GM: Evidence that parathyroid hormone is not required for phosphate homeostasis in renal failure. Metabolism 24: 199, 1975.PubMedCrossRefGoogle Scholar
  4. 4.
    Chen, Jr. PS, Toribara TY and Warner H: Microdetermination of phosphorus. Anal Chem 28: 1756, 1956.CrossRefGoogle Scholar
  5. 5.
    Wen SF: Micropuncture studies of phosphate transport in the proximal tubule of the dog. The relationship to sodium reabsorption. J Clin Invest 53: 143, 1974.PubMedCrossRefGoogle Scholar
  6. 6.
    Vurek GG and Pegram SE: Fluorometric method for determination of nanogram quantities of inulin. Anal Biochem 16: 409, 1966.CrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1978

Authors and Affiliations

  • Sung-Feng Wen
    • 1
  • James W. BoynarJr.
    • 1
  • Robert W. Stoll
    • 1
  1. 1.Department of MedicineUniversity of Wisconsin Center for Health SciencesMadisonUSA

Personalised recommendations