Microcapsule Drug Delivery Systems

  • Joseph A. Bakan
Part of the Polymer Science and Technology book series (POLS, volume 8)


Microencapsulation, a new and rapidly expanding technology pioneered by the NCR Corporation, is receiving considerable attention both industrially and academically. Microencapsulation is a process designed to reproducibly apply thin polymeric coatings to small particles of solids, droplets of liquid (pure or solutions), or dispersions. For the purposes of this discussion, microencapsulation will be arbitrarily differentiated from macrocoating techniques in that the former involves the coating of particles ranging dimensionally from several tenths of a micron to 5, 000 microns in size. A unique feature of this micropackaging technique is in the minuteness of the coated particles and their subsequent potential usefulness in handling physiologically active materials in a variety of dose forms.


Liquid Crystal Core Material Cholesteric Liquid Crystal Hard Gelatin Capsule Cellulose Acetate Phthalate 


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Brynko, C., U. S. Patent 2, 969, 330 (1961).Google Scholar
  2. 2.
    Brynko, C., Bakan, J. A., Miller, R. E., and Scarpelli, J. A., U. S. Patent 3, 341, 466 (1967).Google Scholar
  3. 3.
    Brynko, C., Olderman, G., U. S. Patent 3, 516, 943 (1970).Google Scholar
  4. 4.
    Green, B. K., U. S. Patent 2, 730, 456 (1956).Google Scholar
  5. 5.
    Green, B. K., et al., U. S. Patent 2, 870, 457 (1959).Google Scholar
  6. 6.
    Herbig, J. A., in Encyclopedia of Chemical Technology, 2nd ed, R. E. Kirk and D. F. Othmer, Eds., Interscience Publishers, John Wiley and Sons, New York, 1967, Vol. 13, p. 436.Google Scholar
  7. 7.
    Herbig, J. A., and Hanny, J. F., U. S. Patent 3, 161, 602 (1964).Google Scholar
  8. 8.
    Heistand, E. N., Wagner, J. G., and Knoechel, E. L., U. S. Patent 3, 242, 051 (1966).Google Scholar
  9. 9.
    Miller, R. E., and Anderson, J. L., U. S. Patent 3, 155, 590 (1964).Google Scholar
  10. 10.
    Powell, T. C., Steinle, M. E., and Yoncoski, R. A., U. S. Patent 3, 415, 758 (1968).Google Scholar
  11. 11.
    The Condensed Chemical Dictionary, 4th ed, Reinhold Publishing Co., New York, 1950, p. 178.Google Scholar
  12. 12.
    Bakan, J. A., and Anderson, J. L., in The Theory and Practice of Industrial Pharmacy, L. Lachman, H. Liberman, and J. Kanig, Eds., Lea & Febiger, Philadelphia, Pa., 1970, p. 384.Google Scholar
  13. 13.
    Bakan, J. A., presented at Land O’Lakes Industrial Pharmaceutical Conference, June, 1966.Google Scholar
  14. 14.
    Bakan, J. A., presented at Eastern Regional IPT Section, Academy of Pharmaceutical Sciences, Philadelphia, Pa. October, 1968.Google Scholar
  15. 15.
    Bell, S. A., Berdick, M., and Holliday, W. M., J. New Drugs, 6, September–October, 1966.Google Scholar
  16. 16.
    Chameleon Compounds, Science News, September, 1968.Google Scholar
  17. 17.
    Churchill, D., Cartmell, J., Miller, R., British Patent 1, 138, 590 (1969).Google Scholar
  18. 18.
    Encapsulated Liquid Crystals, NCR Brochure.Google Scholar
  19. 19.
    Gardner, G. L., presented at the Symposium on Pharmaceutical Processing, 58th Annual Meeting, Philadelphia, Pa., December, 1965.Google Scholar
  20. 20.
    Tricoire, J., Presse Med., 78, 2481 (1970).Google Scholar
  21. 21.
    Potanin, C., presented at the 19th Annual Scientific Session of the American College of Cardiology, New Orleans, La., February–March, 1970.Google Scholar
  22. 22.
    Potanin, C., Russell, R. O., Jr., Rackley, C. E., and Dodge, H. T., Lancet, 2, 663 (1969).CrossRefGoogle Scholar
  23. 23.
    Tricoire, J., Mariel, L., Amiel, J. P., et al., Presse Med., 78, 2483 (1970).Google Scholar
  24. 24.
    Bakan, J. A. and Sloan, F. D., Drug Cosmet. Ind., 110, 34 (1972).Google Scholar

Copyright information

© Plenum Press, New York 1975

Authors and Affiliations

  • Joseph A. Bakan
    • 1
  1. 1.Research and Development Capsular Products DivisionNCR CorporationDaytonUSA

Personalised recommendations