Abstract
Chlorphentermine, known as an anoretic drug, has been reported by Franken and associates to induce the formation of foamy cells in the lungs of rats (1). Subsequently, several investigators have described cytoplasmic inclusion bodies in the viscera (2–9) which are considered to be the experimental counterpart of human lipidosis.
This work was supported by a grant from the National Tay-Sachs and Allied Diseases Association, Inc.
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Franken, G., Lüllmann, H. and Siegfriedt, A.: The occurrence of huge cells in pulmonary alveoli of rats treated by an anorexic drug. Arzneimittel-Forsch., 20: 417, 1970.
Kiesel, I.: Grosse Zellen in der Rattenlunge nach Anwendung von Chlorphentermin. Qupt. in Ref. 3.
Lüllmann-Rauch, R., Reil, G.H., Rossen, E., and Seiler, K.U.: The ultrastructure of rat lung changes induced by an anorectic drug (chlorphentermine). Virchows Arch. B Zellpath., 11: 167, 1972.
Lüllmann, H., Lüllmann-Rauch, R. and Reil, G.H.: A comparative ultrastructural study of the effects of chlorphentermine and triparanol in rat lung and adrenal gland. Virchows Arch. B Zellpath., 12: 91, 1973.
Lüllmann-Rauch, R.: Chlorphentermine-induced ultrastructural alterations in foetal tissues. Virchows Arch. B Zellpath., 12: 295, 1973.
Lüllmann-Rauch, R. and Reil, G.H.: Chlorphentermine-induced ultrastructural changes in liver tissues of four animal species. Virchows Arch. B Zellpath., 13: 307, 1973.
Adachi, M., Tsai, C.-Y., Wellmann, K.F. and Volk, B.W.: Ultrastructural alterations of liver, lung, pancreas and CNS of mice induced by chlorphenter-mine. Fed. Proc., 33: 607, 1974.
Lüllmann-Rauch, R., and Pietschmann, N.: Lipidosislike cellular alterations in lymphatic tissues of chlorphentermine-treated animals. Virchows Arch. B Zellpath., 15: 295, 1974.
Lüllmann-Rauch, R.: Lipidosis-like renal changes in rats treated with chlorphentermine or with tricyclic antidepressants. Virchows Arch. B Cell Path., 18: 51, 1975.
Adachi, M., Torii, J., Schneck, L. and Volk, B.W.: The fine structure of fetal Tay-Sachs disease. Arch. Path., 91: 48, 1971.
Schneck, L., Adachi, M. and Volk, B.W.: The Fetal aspects of Tay-Sachs disease. Pediatrics, 49: 342, 1972.
Terry, R.D. and Weiss, M.: Studies on Tay-Sachs disease: II. Ultrastructure of the cerebellum. J. Neuropath. Exp. Neurol., 22: 18, 1963.
Gonatas, N., and Gonatas, J.: Ultrastructural and biochemical observations on a case of systemic late infantile lipidosis and its relationship to Tay-Sachs disease and gargoylism. J. Neuropath. Exp. Neurol., 24: 318, 1965.
Wallace, B.J., Volk, B.W. and Lazarus, S.S.: Fine structural localization of acid phosphatase activity in neurons of Tay-Sachs disease. J. Neuropath. Exp. Neurol., 23: 676, 1964.
Wallace, B.J., Volk, B.W., Schneck, L. and Kaplan, H.: Fine structural localization of two hydrolytic enzymes in the cerebellum of children with lipidoses. J. Neuropath. Exp. Neurol., 25: 76, 1966.
Volk, B.W. and Wallace, B.J.: The liver in lipidosis. An electron microscopic and histochemical study. Am. J. Path., 49: 203, 1966.
Wallace, B.J., Lazarus, S.S. and Volk, B.W.: Electron microscopic and histochemical studies of viscera in lipidoses. In: Inborn Disorders of Sphingolipid Metabolism. Aronson, S.M. and Volk, B.W. (Eds.). New York, Pergamon Press, 1967, P.107.
De Duve, C.: Lysosomes, a new group of cytoplasmic particles. In: Subcellular Particles. Hayashi, T. (Ed.). New York, Ronald Press, 1959, p. 128.
Anzil, A.P., Herrlinger, H. and Blinzinger, K.: Lipidose des Nervensystems nach Chlorphentermin-Applikation. Naturwissenschaften, 61: 35, 1974.
Blinzinger, K., Anzil, A.P. and Herrlinger, H.: Intravitale Tellur-Markierung lysosomaler Speicherorganellen bei exogener Lipidose. Naturwissenschaften, 61: 83, 1974.
Lüllmann-Rauch, R.: Retinal lesions in rat after treatment with chlorphentermine or with tricyclic antidepressants. Virchows Arch. B Zellpath., 15: 309, 1974.
Lüllmann-Rauch, R.: Lipidosis-like alterations in spinal cord and cerebellar cortex of rats treated with chlorphentermine or tricyclic antidepressants. Acta Neuropath., 29: 237, 1974.
Schmien, R., Seiler, K.U. and Wassermann, O.: Druginduced phospholipidosis. I. Lipid composition and chlorphentermine content of rat lung tissue and alveolar macrophages after chronic treatment. Naunyn-Schmiedberg’s Arch. Pharmacol., 283: 331, 1974.
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Adachi, M., Tsai, CY., Greenbaum, M., Mask, B., Volk, B.W. (1976). Ultrastructure and Biochemical Studies of Rat CNS and Viscera after Subcutaneous Injection of Chlorphentermine. In: Volk, B.W., Schneck, L. (eds) Current Trends in Sphingolipidoses and Allied Disorders. Advances in Experimental Medicine and Biology, vol 68. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-7735-1_29
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DOI: https://doi.org/10.1007/978-1-4684-7735-1_29
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