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Studies in Metachromatic Leukodystrophy. XIII. Purification of Sulfatase A from Normal Human Liver

  • Janet Collins
  • Warren Yamada
  • William Worth
  • James Austin
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 68)

Abstract

Metachromatic leukodystrophy (MLD) is a genetically-determined neurolipidosis characterized by deficient activity of sulfatase A (cerebroside sulfatase) and by the resultant accumulation of cerebroside sulfate. Immunological studies using a monospecific antibody to sulfatase A have shown that MLD patients do have the enzyme protein (7). The reason why this protein has little or no activity is not yet clear. The first step in such a study is to isolate and characterize the normal sulfatase.

Keywords

Aryl Sulfatase Metachromatic Leukodystrophy Normal Human Liver Purify Enzyme Preparation Aryl Sulfatase Acti 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1976

Authors and Affiliations

  • Janet Collins
    • 1
  • Warren Yamada
    • 1
  • William Worth
    • 1
  • James Austin
    • 1
  1. 1.Department of NeurologyUniversity of Colorado Medical CenterDenverUSA

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