Biochemical and Immunochemical Studies of the β-Adrenergic Receptor

  • A. Donny Strosberg
Part of the NATO Advanced Study Institutes Series book series (NSSA, volume 44)


Cell-cell interactions in multicellular organisms involve molecular recognition mechanisms in which soluble messengers such as hormones, neurotransmitters, antigens and mitogens and cell-bound receptors play a major role. Complex networks of interacting ligands and cells have been described in areas as diverse as endocrinology, immunology and neurobiology. Few receptor-ligands systems have however been studied at the molecular level and even fewer receptors have been isolated and characterized. The main difficulty rests with the low number of receptors per cell and the ignorance of which components are necessary to isolate active molecules. A striking exception is the acetylcholine receptor whose amino acid sequence determination is now under way1,2.


Adenylate Cyclase Guanine Nucleotide Adenylate Cyclase Stimulation Guanyl Nucleotide Frog Erythrocyte 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    J. Giraudat and J. P. Changeux, Trends in Pharmacol. Sci.198–202 (1980).Google Scholar
  2. 2.
    A. Devillers-Thiery, J. P. Changeux, P. Paroutaud and A. D. Strosberg, FEBS Lett. 104: 99–105 (1979).CrossRefGoogle Scholar
  3. 3.
    A. D. Strosberg, G. Vauquelin, O. Durieu-Trautmann, C. Delavier-Klutchko, S. Bottari and C. Andr, Trends in Biochem. Sci. 5: 11–14 (1980).CrossRefGoogle Scholar
  4. 4.
    A. Levitzki and E. Helmreich, FEBS Lett. 101: 213–219 (1979).PubMedCrossRefGoogle Scholar
  5. 5.
    M. Rodbell, Nature 284: 17–22 (1980).PubMedCrossRefGoogle Scholar
  6. 6.
    R. J. Lefkowitz, Ann. Int. Med. 91: 450–458 (1979).Google Scholar
  7. 7.
    L. E. Limbird and R.J. Lefkowitz, J. Biol. Chem. 252: 799–802 (1977).PubMedGoogle Scholar
  8. 8.
    G. Vauquelin, P. Geynet, J. Hanoune and A. D. Strosberg, Eur. J. Biochem. 98: 543–556 (1979).PubMedCrossRefGoogle Scholar
  9. 9.
    T. Haga, K. Haga and A. G. Gilman, J. Biol. Chem. 252: 5776–5782 (1977).PubMedGoogle Scholar
  10. 10.
    G. Vauquelin, P. Geynet, J. Hanoune and A. D. Strosberg, Proc. Natl, Acad, Sci. U.S.A. 74: 3710–3714 (1977).CrossRefGoogle Scholar
  11. 11.
    Durieu-Trautmann, C. Delavier-Klutchko, G. Vauquelin and A. D. Strosberg, J. Supramol. Struct. in press.Google Scholar
  12. 12.
    G. Vauquelin, S. Bottari, L. Kanarek and A.D. Strosberg, J. Biol. Chem. 254:4462–4449 (1979).Google Scholar
  13. 13.
    S. Bottari, G. Vauquelin, 0. Durieu-Trautmann, C. DelavierKlutchko and A. D. Strosberg, Biochem. Biophys. Res. Commun. 86: 1311–1318 (1979).Google Scholar
  14. 14.
    G. Vauquelin, S. Bottari and A. D. Strosberg, Mol. Pharmacol.17:163–171 (1979).Google Scholar
  15. 15.
    E. M. Ross, A. C. Howlett, M. Ferguson and A. D. Gilman J. Biol. Chem. 253: 6401–6412 (1978).Google Scholar
  16. 16.
    D. Cassel and T. Pfeuffer, Proc. Natl. Acad. Sci. 75: 2669–2673 (1978).PubMedCrossRefGoogle Scholar
  17. 17.
    D. Cassel and Z. Selinger, Proc. Natl. Acad. Sci. 74: 3307–3311 (1977).PubMedCrossRefGoogle Scholar
  18. 18.
    G. Vauquelin, S. Bottari, C. André, B. Jacobsson and A. D. Strosberg, Proc. Natl. Acad. Sci. 77: 3801–3805 (1980).PubMedCrossRefGoogle Scholar
  19. 19.
    J. M. Stadel, A. Delean, and R. J. LefkowitzJ. Biol. Chem.255:1436–1441 (1980).Google Scholar
  20. 20.
    P. M. Lad, T. B. Nielsen, M. S. Preston and M. Rodbell, J. Biol. Chem. 255: 988–995 (1980).Google Scholar
  21. 21.
    M. E. Maguire, E. M. Ross and A. G. Gilman, Adv. Cyclic Nucleotide Res. 8: 1–83 (1977).Google Scholar
  22. 22.
    S. J. Bird and M. E. Maguire, J. Biol. Chem. 253: 8826–8834 (1978).PubMedGoogle Scholar
  23. 23.
    C. Delavier-Klutchko, 0. Durieu-Traumann, P. 0. Couraud, C. André and A. D. Strosberg, FEBS Lett. 117: 341–343 (1980).CrossRefGoogle Scholar
  24. 24.
    J. Orly and M. Schramm, Proc. Natl. Acad. Sci. U.S.A. 73: 4410–4414 (1976).PubMedCrossRefGoogle Scholar
  25. 25.
    L. J. Pike, L. E. Limbird and R. J. Lefkowitz, Nature 280: 502–504 (1979).PubMedCrossRefGoogle Scholar
  26. 26.
    K. Sege and P. A. Peterson, Proc. Natl. Acad. Sci. U.S.A. 75: 24432447 (1978).Google Scholar
  27. 27.
    A. B. Schreiber, P. 0. Couraud, C. André, B. Vray and A. D. StrosbergProc. Natl. Acad. Sci. U.S.A. in press.Google Scholar
  28. 28.
    P. 0. Couraud, C. Delavier-Klutchko, 0. Durieu-Trautmann and A. D. Strosberg, Abst. Proc. Fourth. Internat. Conf. Cyclic Nucleotides Brussels.Google Scholar

Copyright information

© Springer Science+Business Media New York 1982

Authors and Affiliations

  • A. Donny Strosberg
    • 1
  1. 1.Molecular ImmunologyIRBM - CNRS and University of Paris VIIParisFrance

Personalised recommendations