α-Adrenergic and Cholinergic Control of Cyclic Nucleotide Metabolism

  • Karl H. Jakobs
  • Günter Schultz
Part of the NATO Advanced Study Institutes Series book series (NSSA, volume 44)


A large variety of hormones and neurotransmitters elicits specific cellular responses that reach their maximum within a few minutes. These hormonal effects are mediated by membrane-bound receptors and generally involve intracellular signals or “second messengers”. One part of these fast cellular hormone responses is triggered by an increased formation of cyclic AMP. The effects of β-adrenergic agonists, of histamine via H2-receptors, some effects of prostaglandins (e.g., PGE1, PGD2 and PGI2 in platelets), of adenosine (in platelets) and of some polypeptide hormones, e.g., glucagon, belong to this groupl.


Adenylate Cyclase Cholinergic Agonist Adenylate Cyclase Inhibition Cholinergic Control Glioma Hybrid Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Robison, G.A., Butcher, R.W., and Sutherland, E.W. (1971) Cyclic AMP. Academic Press, New York and London.Google Scholar
  2. 2.
    Williams, L.T., and Lefkowitz, R.J. (1978) Receptor Binding Studies in Adrenergic Pharmacology. Raven Press, New York.Google Scholar
  3. Michell, R.H. (1975) Biochim. Biophys. Acta 415:81–147.Google Scholar
  4. 4.
    Jones, L.M., and Michell, R.H. (1978) Biochem. Soc. Transact. 6:673–688.Google Scholar
  5. Jakobs, K.H. (1979) Mol. Cell. Endocrinol. 16:147–156.Google Scholar
  6. 6.
    Jakobs, K.H., Aktories, K., Lasch, P., and Schultz, G. (1980) in: Hormones and Cell Regulation Vol. 4, ed. by J.E. Dumont and J. Nunez, North-Holland, Amsterdam, pp. 89–106.Google Scholar
  7. 7.
    Jakobs, K.H., Aktories, K., and Schultz, G. (1981) Adv. Cyclic Nucleotide Res. 14: in press.Google Scholar
  8. 8.
    Rodbell, M. (1980) Nature 284:17–22.PubMedCrossRefGoogle Scholar
  9. 9.
    Abramowitz, J., Iyengar, R., and Birnbaumer, L. (1979) Mol. Cell. Endocrinol. 16:129–146.PubMedCrossRefGoogle Scholar
  10. 10.
    Cassel, D., Levkovitz, H., and Selinger, Z. (1977) J. Cyclic Nucleotide Res. 3:393–406PubMedGoogle Scholar
  11. 11.
    Pfeuffer, T. (1977) J. Biol. Chem. 252:7224–7234.PubMedGoogle Scholar
  12. 12.
    Howlett, A.C., and Gilman, A.G. (1980) J. Biol. Chem. 255:2861–2866.PubMedGoogle Scholar
  13. 13.
    Kaslow, H.R., Johnson, G.L., Brothers, V.M., and Bourne, H.R. (1980) J. Biol. Chem. 255: 3736–3741.PubMedGoogle Scholar
  14. 14.
    Goldberg, N.D., and Haddox, M.K. (1977) Ann. Rev. Biochem. 46: 823–896.PubMedCrossRefGoogle Scholar
  15. 15.
    Schultz, G., Hardman, J.G., Schultz, K., Baird, C.E., and Sutherland, E.W. (1973) Proc. Natl. Acad. Sci. USA 70:3889–3893.PubMedCrossRefGoogle Scholar
  16. 16.
    Clyman, R.I., Blacksin, A.S., Manganiello, V.C., and Vaughan, M. (1975) Proc. Natl. Acad. Sci. USA 72:3883–3887.PubMedCrossRefGoogle Scholar
  17. 17.
    DeRubertis, F.R., and Craven, P.A. (1978) Metabolism 27: 855–868.PubMedCrossRefGoogle Scholar
  18. 18.
    Murad, F., Arnold, W.P., Mittal, C.K., and Braughler, J.M. (1979) Adv. Cyclic Nucleotide Res. 11:175–204.Google Scholar
  19. 19.
    Graff, G., Stephenson, J.H., Glass, D.B., Haddox, M.K., and Goldberg, N.D. (1978) J. Biol. Chem. 253:7662–7676.Google Scholar
  20. 20.
    Hidaka, H., and Asano, T. (1977) Proc. Natl. Acad. Sci. USA 74:3657–3661.CrossRefGoogle Scholar
  21. 21.
    Mittal, C.K., and Murad, F. (1977) Proc. Natl. Acad. Sci. USA 74:4360–4364.CrossRefGoogle Scholar
  22. 22.
    Spies, C., Schultz, K.-D., and Schultz, G. (1980) NaunynSchmiedeberg’s Arch. Pharmacol. 311:71–77.Google Scholar
  23. 23.
    Glass, D.B., Gerrard, F.M., Townsend, D., Carr, D.W., White, J.G., and Goldberg, N.D. (1977) J. Cyclic Nucleotide Res. 3:37–44.PubMedGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1982

Authors and Affiliations

  • Karl H. Jakobs
    • 1
  • Günter Schultz
    • 1
  1. 1.Pharmakologisches InstitutUniversität HeidelbergHeidelbergGermany

Personalised recommendations