Contribution of the Theoretical Simulation to the Mechanistic Description of a Biochemical System: Application to the Adenylate Cyclase System
The advance in the mechanistic description of a biochemical system is the natural consequence of the accumulation of experimental results. The interpretation of these results usually leads to a general scheme describing the relations between the different components of the system. Such a scheme is, more often than not, a set of descriptive sentences, which are sometimes illustrated by a picture where arrows and conventional signs define biochemical interactions between the constituents. Less frequently is presented a complete description of the system in terms of component concentrations and of kinetic parameters of the reactions. Only in this latter case, the description might be referred to as a model of the system, since it contains the whole information required for generating the behaviour of the experimental system.
KeywordsAdenylate Cyclase Guanine Nucleotide Receptor Occupancy Adenylate Cyclase Activation Biochemical System
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