Regulation of Gastric Acid Secretion
Despite the fact that increased gastric acid secretion is not diagnostic for peptic ulcer disease, it is generally believed that where there is no acid there is no ulcer. Thus, there remains a strong medical interest in the understanding of the cellular regulation of gastric acid secretion by the major secretagogues, histamine, gastrin and acetylcholine and therapy designed to interfere with this regulation. Released as a result of various physiological stimuli, including food, these paracrine, endocrine, and neurohumoral agents act by both direct and indirect pathways to effect the production and secretion of hydrogen ions from parietal cells located in the lower portion of the oxyntic glands in the fundic stomach. Recently, the study of gastric acid secretion has been advanced by the advent of methods to isolate gastric oxyntic glands and gastric parietal cells. These preparations have allowed the formulation of new concepts to explain in vivo and in vitro physiological and pharmacological data derived from studies on the interactions of hormones that regulate the acid secretory process14,17,20.
KeywordsAcid Secretion Parietal Cell Gastric Acid Secretion Gastrin Release Gastric Parietal Cell
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