Actions of Lutropin (LH) and cAMP in the Regulation of Testicular Steroid Production
The two main physiological functions of the mammalian testis are localized in different tissue compartments; spermatogenesis occurs within the seminiferous tubules and steroid hormone production within the interstitial tissue. Within the interstitial tissue the Leydig cells are the main, if not the only source of de novo steroid production. Trophic hormones from the pituitary are intimately involved in the maintenance and regulation of these testis functions. Follitropin (FSH) is known to have specific effects on the Sertoli cells of the seminiferous tubules, but has no known effect on cells in the interstitial tissue. Lutropin (LH) specifically interacts with Leydig cells in the interstitial compartment, but has no direct effects on the seminiferous tubules. The testis Leydig cells have become increasingly interesting as a model for studying the biochemical mechanisms involved in the actions of trophic hormones on steroid production, because recent technical developments have made it possible to study specific hormone-biochemical parameters in specific isolated testis cells.
KeywordsLuteinizing Hormone Leydig Cell Seminiferous Tubule Interstitial Tissue Testosterone Production
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