Cyclic Nucleotides and Cell Growth

  • Jaques Otten
Part of the NATO Advanced Study Institutes Series book series (NSSA, volume 44)


The discovery of cyclic AMP as an intracellular messenger for many hormonally-controlled functions and more generally of its involvement in the regulation of cell response to exogenous effectors led to the hypothesis that the adenylate cyclase-cyclic AMP system might also have a role in the regulation of cell division. Indeed, starting or stopping growth, increasing or decreasing growth velocity are among the most important adaptive responses to a changing environment. The ubiquitous character of cyclic AMP in all animal cells made of this substance a good candidate for a universal growth regulator.


Cyclic Nucleotide Epidermal Skin Cell Ubiquitous Character Decrease Growth Velocity Baby Hamster Kidney Fibroblast 


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Copyright information

© Springer Science+Business Media New York 1982

Authors and Affiliations

  • Jaques Otten
    • 1
  1. 1.Institut de Recherche InterdisciplinaireUniversité Libre de BruxellesBruxellesBelgium

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