Cyclic Nucleotides and Cell Growth
The discovery of cyclic AMP as an intracellular messenger for many hormonally-controlled functions and more generally of its involvement in the regulation of cell response to exogenous effectors led to the hypothesis that the adenylate cyclase-cyclic AMP system might also have a role in the regulation of cell division. Indeed, starting or stopping growth, increasing or decreasing growth velocity are among the most important adaptive responses to a changing environment. The ubiquitous character of cyclic AMP in all animal cells made of this substance a good candidate for a universal growth regulator.
KeywordsCyclic Nucleotide Epidermal Skin Cell Ubiquitous Character Decrease Growth Velocity Baby Hamster Kidney Fibroblast
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