The Effects of Cyclic Nucleotide Derivatives on Cell Metabolism
Analogs of cAMP and cGMP are commonly used to clarify the role of cyclic nucleotides in cell metabolism. Shortly after Sutherlands discovery of cAMP, chemists started to modify the molecule according the general rules of chemical synthesis1. Already at that time the best known cAMP analog — 6N2 ´ 0-dibutyryl cAMP — was synthesized by Posternak et al. and introduced into biochemical and biological studies. Many chemists from all over the world followed Posternak in the synthesis of analogs and thus up to today more than 600 derivatives of the natural cyclic nucleotides have been reported2. In principle modifications of these molecules can continue endlessly, since the multifunctional character of the nucleotide structure allows unlimited modifications1. Most of the derivatives were synthesized between 1968–1973 by chemists in the pharmaceutical industry, because at that time all the companies searched for a drug based on the structure of a cyclic nucleotide.
KeywordsCyclic Nucleotide Amino Acid Side Chain Atom Group cAMP Analog cAMP Receptor Protein
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