Cyclic Nucleotide Metabolism in Whole Cells
While we have learned a great deal about the enzymes of cyclic AMP metabolism, the control of intracellular cyclic AMP levels is only dimly perceived. This is partly because of the way in which cyclic AMP was discovered: this discovery was in fact the logical outcome of a beautiful series of experiments by Sutherland, Rall and their co-workers, designed to show that a hormone (epinephrine) could work in cell-free systems. That hormones could do so was not a popular notion at the time, so they attempted to relate, at least in qualitative fashion, events occurring in homogenates or subcellular fractions to those known to occur in the intact tissue’. How well they succeeded is evidenced by this NATO course.
KeywordsAdenylate Cyclase Cyclic Nucleotide Intracellular cAMP cAMP Accumulation Adenylate Cyclase System
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