Kaliomimetic Ion Transport by Injured Membrane During in Vitro Hyperthermia of Tumor Cells
Despite the fact that the mechanisms responsible for tumor cell death during hyperthermia are not well known, there is evidence that cell membrane changes related to small temperature variations are the possible cause of the phenomenon. Hyperthermia changes the physical and chemical characteristics of the lipid double layer at the plasma membrane level with consequent modification of permeability to big molecules.1,2 Early changes of cell membrane function may be assessed by means of radiotracers. Smigielski and Janiak3 have demonstrated hyperthermia-induced early damage to the cell membrane by alteration of 86Rb transmembrane transport.
KeywordsTumor Cell Death Blood Flow Modification Potassium Transport Cell Mortality Radioactivity Uptake
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